Continuous artery-selective spin labeling (CASSL)

Richard Werner*, David G. Norris, Karsten Alfke, H. Maximilian Mehdorn, Olav Jansen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)


A new technique for selective spin labeling of individual arteries is presented. It is based on continuous arterial spin labeling (CASL) with an amplitude-modulated control experiment. Precessionary motion of the labeling gradient about the axis of the artery, combined with an appropriate frequency modulation of the labeling RF pulse, restricts the adiabatic inversion to the desired artery. In phantom studies, it was found that the level of selectivity could be controlled by the sequence parameters, and that the achievable labeling efficiency was at a level of ∼80% compared to a regular, nonselective CASL experiment. In a volunteer study we acquired high-quality images of the perfusion territories of the internal carotid artery (ICA), the basilar artery (BA), the middle cerebral artery (MCA), and both anterior cerebral arteries (ACAs). The results show the method's flexibility for different geometries and flow velocities. Potential applications include perfusion territory imaging of smaller cerebral arteries, and selective angiography techniques.

Original languageEnglish
Pages (from-to)1006-1012
Number of pages7
JournalMagnetic resonance in medicine
Issue number5
Publication statusPublished - May 2005
Externally publishedYes


  • Cerebral arteries
  • Continuous arterial spin labeling
  • Perfusion territories
  • Perfusion territory imaging
  • Selective arterial labeling
  • n/a OA procedure


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