Continuous Flow Versus Stopped flow in A Micro flow Injection System

E.B. van Akker, M. Bos, A. van den Berg, W.E. van der Linden

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


    The effects of continuous, pulsed and stopped flow on the dispersion of a dye in a micro flow injection system were studied experimentally and by digital simulation. A channel of 200 μm by 200 μm by 21550 μm was used to compare experimental results with the numerical results. Furthermore the injection of the dye into the flow system was studied. Video recordings of the injection were compared to simulations during and just after the injection.

    Different flow rates ranging from 0.5 to 5.0 μl/min were used to study the continuous flow. The time where the flow was stopped to study the effect on the dispersion ranged from 10 to 400 seconds. The pulse frequency, to study the pulsed flow, ranged from 6 Hz to 0.1 Hz.

    The numerical model used in this paper shows an excellent agreement with the experimental values obtained. The video recordings compared to numerical simulations show that the numerical model could be used to model the injection.

    The general numerical model allows the calculating of the flow profile, pressure distribution and the concentration distribution of the sample, three dimensional, throughout an arbitrary channel.
    Original languageEnglish
    Title of host publicationMicro Total analysis Systems '98
    Subtitle of host publicationProceedings of the uTAS ’98 Workshop, held in Banff, Canada, 13–16 October 1998
    EditorsD. Jed Harrison, Albert van den Berg
    Place of PublicationDordrecht
    PublisherKluwer Academic Publishers
    ISBN (Electronic)978-94-011-5286-0
    ISBN (Print)978-94-010-6225-1
    Publication statusPublished - 13 Oct 1998
    Event3rd International Workshop on Micro Total Analysis Systems, μTAS 1998 - Banff, Canada
    Duration: 13 Oct 199816 Oct 1998
    Conference number: 3


    Workshop3rd International Workshop on Micro Total Analysis Systems, μTAS 1998
    Abbreviated titleMicroTAS


    • Flow-injection
    • Numerical modeling


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