Control of oxygen release from peroxides using polymers

Hilde Steg, Arina T. Buizer, Willem Woudstra, Albert G. Veldhuizen, Sjoerd K. Bulstra, Dirk W. Grijpma, Roel Kuijer (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

An important limitation in cell therapy for the regeneration of tissue is the initial lack of oxygen. After implantation of large 3D cell-seeded structures, cells die rather than contribute to tissue regenerating. Here we’ve tested oxygen-releasing materials to improve cell survival and growth after implantation. Calcium peroxide (CaO2) in a polymer matrix was used as source of oxygen. Two polymers were tested in order to slow down and extend the period of oxygen release, poly(D,L-lactic acid) and poly(lactic-co-glycolic acid). Compared to CaO2 particles, both releasing systems showed an initially higher and shorter oxygen release. Human mesenchymal stromal cells cultured on casted films of these oxygen-releasing composites required catalase to proliferate, indicating the production of cytotoxic hydrogen peroxide as intermediate. Poly(D,L-lactic acid) and poly(lactic-co-glycolic acid) are less suited for slowly oxygen-releasing materials. Catalase was able to reduce the cytotoxic effect of H2O2.
Original languageEnglish
Article number207
Number of pages4
JournalJournal of materials science. Materials in medicine
Volume26
Issue number207
DOIs
Publication statusPublished - 2015

Keywords

  • METIS-315299
  • IR-99654

Fingerprint Dive into the research topics of 'Control of oxygen release from peroxides using polymers'. Together they form a unique fingerprint.

  • Cite this

    Steg, H., Buizer, A. T., Woudstra, W., Veldhuizen, A. G., Bulstra, S. K., Grijpma, D. W., & Kuijer, R. (2015). Control of oxygen release from peroxides using polymers. Journal of materials science. Materials in medicine, 26(207), [207]. https://doi.org/10.1007/s10856-015-5542-z