Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers

R. van Dijkhuizen-Radersma, S. Métairie, J.R. Roosma, K. de Groot, J.M. Bezemer

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.
Original languageUndefined
Pages (from-to)175-186
JournalJournal of controlled release
Volume101
Issue number1-3
DOIs
Publication statusPublished - 7 Apr 2005

Keywords

  • Protein release
  • Diffusion
  • METIS-230077
  • Poly(ether ester)
  • Degradable
  • IR-77762
  • Delayed release

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