Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers

R. van Dijkhuizen-Radersma, S. Métairie, J.R. Roosma, K. de Groot, J.M. Bezemer

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.
Original languageUndefined
Pages (from-to)175-186
JournalJournal of controlled release
Volume101
Issue number1-3
DOIs
Publication statusPublished - 7 Apr 2005

Keywords

  • Protein release
  • Diffusion
  • METIS-230077
  • Poly(ether ester)
  • Degradable
  • IR-77762
  • Delayed release

Cite this

van Dijkhuizen-Radersma, R., Métairie, S., Roosma, J. R., de Groot, K., & Bezemer, J. M. (2005). Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers. Journal of controlled release, 101(1-3), 175-186. https://doi.org/10.1016/j.jconrel.2004.08.014
van Dijkhuizen-Radersma, R. ; Métairie, S. ; Roosma, J.R. ; de Groot, K. ; Bezemer, J.M. / Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers. In: Journal of controlled release. 2005 ; Vol. 101, No. 1-3. pp. 175-186.
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abstract = "A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.",
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van Dijkhuizen-Radersma, R, Métairie, S, Roosma, JR, de Groot, K & Bezemer, JM 2005, 'Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers', Journal of controlled release, vol. 101, no. 1-3, pp. 175-186. https://doi.org/10.1016/j.jconrel.2004.08.014

Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers. / van Dijkhuizen-Radersma, R.; Métairie, S.; Roosma, J.R.; de Groot, K.; Bezemer, J.M.

In: Journal of controlled release, Vol. 101, No. 1-3, 07.04.2005, p. 175-186.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers

AU - van Dijkhuizen-Radersma, R.

AU - Métairie, S.

AU - Roosma, J.R.

AU - de Groot, K.

AU - Bezemer, J.M.

N1 - Special Issue: Proceedings of the Eighth European Symposium on Controlled Drug Delivery

PY - 2005/4/7

Y1 - 2005/4/7

N2 - A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.

AB - A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.

KW - Protein release

KW - Diffusion

KW - METIS-230077

KW - Poly(ether ester)

KW - Degradable

KW - IR-77762

KW - Delayed release

U2 - 10.1016/j.jconrel.2004.08.014

DO - 10.1016/j.jconrel.2004.08.014

M3 - Article

VL - 101

SP - 175

EP - 186

JO - Journal of controlled release

JF - Journal of controlled release

SN - 0168-3659

IS - 1-3

ER -

van Dijkhuizen-Radersma R, Métairie S, Roosma JR, de Groot K, Bezemer JM. Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers. Journal of controlled release. 2005 Apr 7;101(1-3):175-186. https://doi.org/10.1016/j.jconrel.2004.08.014