Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills

Giulia Ballardini; Izadyar Tamadon; Daniele Guarnera; Hind Al-Haddad; Veronica Iacovacci; Francesco Mariottini; Simone Ricciardi; Alessio Cucini; Alberto Dalla Libera; Fabio Vistoli; Arianna Menciassi; Paolo Dario; Claudio Cobelli; Leonardo Ricotti

doi:10.1109/EMBC40787.2023.10340006

Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills

Giulia Ballardini^*, Izadyar Tamadon, Daniele Guarnera, Hind Al-Haddad, Veronica Iacovacci, Francesco Mariottini, Simone Ricciardi, Alessio Cucini, Alberto Dalla Libera, Fabio Vistoli, Arianna Menciassi, Paolo Dario, Claudio Cobelli, Leonardo Ricotti

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Over the past decade, there has been a growing interest in the development of an artificial pancreas for intraperitoneal insulin delivery. Intraperitoneal implantable pumps guarantee more physiological glycemic control than subcutaneous wearable ones, for the treatment of type 1 diabetes. In this work, a fully implantable artificial pancreas refillable by ingestible pills is presented. In particular, solutions enabling the communication between the implanted pump and external user interfaces and novel control algorithms to intraperitoneally release an adequate amount of insulin based on glycemic data are shown. In addition, the powering and the wireless battery recharging are addressed. Specifically, the design and optimization of a customized transcutaneous energy transfer with two independent wireless channels are presented. The system was tested in terms of recharging efficacy, possible temperature rise within the body, during the recharging process and reliability of the wireless connection in the air and in the presence of ex vivo tissues.Clinical Relevance - This work aims to improve the control, battery recharging, and wireless communication of a fully implantable artificial pancreas for type 1 diabetes treatment.

Original language	English
Title of host publication	2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings
Publisher	IEEE
ISBN (Electronic)	9798350324471
DOIs	https://doi.org/10.1109/EMBC40787.2023.10340006
Publication status	Published - 2023
Externally published	Yes
Event	45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2023 - Sydney, Australia Duration: 24 Jul 2023 → 27 Jul 2023 Conference number: 45

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2023
Abbreviated title	EMBC 2023
Country/Territory	Australia
City	Sydney
Period	24/07/23 → 27/07/23

Keywords

2024 OA procedure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/EMBC40787.2023.10340006

ArticleFinal published version, 1.37 MBLicence: Taverne

Cite this

Ballardini, G., Tamadon, I., Guarnera, D., Al-Haddad, H., Iacovacci, V., Mariottini, F., Ricciardi, S., Cucini, A., Libera, A. D., Vistoli, F., Menciassi, A., Dario, P., Cobelli, C., & Ricotti, L. (2023). Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills. In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). IEEE. https://doi.org/10.1109/EMBC40787.2023.10340006

Ballardini, Giulia ; Tamadon, Izadyar ; Guarnera, Daniele et al. / Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills. 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. IEEE, 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{d3426ade23cb4a4384ebfe6438962067,

title = "Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills",

abstract = "Over the past decade, there has been a growing interest in the development of an artificial pancreas for intraperitoneal insulin delivery. Intraperitoneal implantable pumps guarantee more physiological glycemic control than subcutaneous wearable ones, for the treatment of type 1 diabetes. In this work, a fully implantable artificial pancreas refillable by ingestible pills is presented. In particular, solutions enabling the communication between the implanted pump and external user interfaces and novel control algorithms to intraperitoneally release an adequate amount of insulin based on glycemic data are shown. In addition, the powering and the wireless battery recharging are addressed. Specifically, the design and optimization of a customized transcutaneous energy transfer with two independent wireless channels are presented. The system was tested in terms of recharging efficacy, possible temperature rise within the body, during the recharging process and reliability of the wireless connection in the air and in the presence of ex vivo tissues.Clinical Relevance - This work aims to improve the control, battery recharging, and wireless communication of a fully implantable artificial pancreas for type 1 diabetes treatment.",

keywords = "2024 OA procedure",

author = "Giulia Ballardini and Izadyar Tamadon and Daniele Guarnera and Hind Al-Haddad and Veronica Iacovacci and Francesco Mariottini and Simone Ricciardi and Alessio Cucini and Libera, {Alberto Dalla} and Fabio Vistoli and Arianna Menciassi and Paolo Dario and Claudio Cobelli and Leonardo Ricotti",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2023, EMBC 2023 ; Conference date: 24-07-2023 Through 27-07-2023",

year = "2023",

doi = "10.1109/EMBC40787.2023.10340006",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "IEEE",

booktitle = "2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings",

address = "United States",

}

Ballardini, G, Tamadon, I, Guarnera, D, Al-Haddad, H, Iacovacci, V, Mariottini, F, Ricciardi, S, Cucini, A, Libera, AD, Vistoli, F, Menciassi, A, Dario, P, Cobelli, C & Ricotti, L 2023, Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills. in 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, IEEE, 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2023, Sydney, Australia, 24/07/23. https://doi.org/10.1109/EMBC40787.2023.10340006

Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills. / Ballardini, Giulia; Tamadon, Izadyar; Guarnera, Daniele et al.
2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. IEEE, 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills

AU - Ballardini, Giulia

AU - Tamadon, Izadyar

AU - Guarnera, Daniele

AU - Al-Haddad, Hind

AU - Iacovacci, Veronica

AU - Mariottini, Francesco

AU - Ricciardi, Simone

AU - Cucini, Alessio

AU - Libera, Alberto Dalla

AU - Vistoli, Fabio

AU - Menciassi, Arianna

AU - Dario, Paolo

AU - Cobelli, Claudio

AU - Ricotti, Leonardo

N1 - Conference code: 45

PY - 2023

Y1 - 2023

N2 - Over the past decade, there has been a growing interest in the development of an artificial pancreas for intraperitoneal insulin delivery. Intraperitoneal implantable pumps guarantee more physiological glycemic control than subcutaneous wearable ones, for the treatment of type 1 diabetes. In this work, a fully implantable artificial pancreas refillable by ingestible pills is presented. In particular, solutions enabling the communication between the implanted pump and external user interfaces and novel control algorithms to intraperitoneally release an adequate amount of insulin based on glycemic data are shown. In addition, the powering and the wireless battery recharging are addressed. Specifically, the design and optimization of a customized transcutaneous energy transfer with two independent wireless channels are presented. The system was tested in terms of recharging efficacy, possible temperature rise within the body, during the recharging process and reliability of the wireless connection in the air and in the presence of ex vivo tissues.Clinical Relevance - This work aims to improve the control, battery recharging, and wireless communication of a fully implantable artificial pancreas for type 1 diabetes treatment.

AB - Over the past decade, there has been a growing interest in the development of an artificial pancreas for intraperitoneal insulin delivery. Intraperitoneal implantable pumps guarantee more physiological glycemic control than subcutaneous wearable ones, for the treatment of type 1 diabetes. In this work, a fully implantable artificial pancreas refillable by ingestible pills is presented. In particular, solutions enabling the communication between the implanted pump and external user interfaces and novel control algorithms to intraperitoneally release an adequate amount of insulin based on glycemic data are shown. In addition, the powering and the wireless battery recharging are addressed. Specifically, the design and optimization of a customized transcutaneous energy transfer with two independent wireless channels are presented. The system was tested in terms of recharging efficacy, possible temperature rise within the body, during the recharging process and reliability of the wireless connection in the air and in the presence of ex vivo tissues.Clinical Relevance - This work aims to improve the control, battery recharging, and wireless communication of a fully implantable artificial pancreas for type 1 diabetes treatment.

KW - 2024 OA procedure

UR - http://www.scopus.com/inward/record.url?scp=85179650162&partnerID=8YFLogxK

U2 - 10.1109/EMBC40787.2023.10340006

DO - 10.1109/EMBC40787.2023.10340006

M3 - Conference contribution

C2 - 38083764

AN - SCOPUS:85179650162

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

BT - 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings

PB - IEEE

T2 - 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2023

Y2 - 24 July 2023 through 27 July 2023

ER -

Ballardini G, Tamadon I, Guarnera D, Al-Haddad H, Iacovacci V, Mariottini F et al. Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills. In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference, EMBC 2023 - Proceedings. IEEE. 2023. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC40787.2023.10340006

Controlling and powering a fully implantable artificial pancreas refillable by ingestible pills

Abstract

Publication series

Conference

Keywords

UN SDGs

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