Controlling the amplification of chirality in hydrogen-bonded assemblies

The amplification of chirality (a high enantiomeric or diastereomeric excess induced by a small initial amount of chiral bias) on hydrogen-bonded assemblies has been studied using “sergeants-and-soldiers” experiments under thermodynamically controlled conditions. Here it is shown that different substitutions and structural variations in the building blocks that form these self-assembled systems can be used to control the extent of the chiral amplification.