TY - GEN
T1 - Coregistered Photoacoustic and ultrasound tomography of healthy and inflamed human interphalangeal joints
AU - van Es, Peter
AU - Vlieg, R.C.
AU - Hondebrink, Erwin
AU - van Hespen, Johannes C.G.
AU - Moens, H.B.
AU - Steenbergen, Wiendelt
AU - Manohar, Srirang
PY - 2015/6/21
Y1 - 2015/6/21
N2 - Photoacoustic (PA) or optoacoustic (OA) imaging combines the high (blood) contrast to light with the high-resolution of ultrasound. The method can visualize vascularization deep inside tissue. Of late there is interest in PA imaging of synovial joints which are expected to be associated with increased vascularization in the event of rheumatoid arthritis (RA). We here describe our approach in investigating the application of the PA technique in arthritis. We are developing a CT-geometry version PA finger imager, intended for early clinical assessment of the method. The imager uses two curved array ultrasound detectors each with 64 elements with central frequencies 1.5 and 7.5 MHz respectively, stacked above each other. Both cover approximately 180 degrees of the circle. Illumination is provided with a multiple of optical fiber bundles coupled to a laser-OPO system. Ultrasound imaging is also possible with the system, since the curved arrays are each provided with 12 or 8 ultrasound pulsers. We have investigated systematically imaging of finger vasculature in healthy volunteers using an earlier laboratory prototype. In this paper we present finger imaging results of a patient diagnosed with rheumatoid arthritis.
AB - Photoacoustic (PA) or optoacoustic (OA) imaging combines the high (blood) contrast to light with the high-resolution of ultrasound. The method can visualize vascularization deep inside tissue. Of late there is interest in PA imaging of synovial joints which are expected to be associated with increased vascularization in the event of rheumatoid arthritis (RA). We here describe our approach in investigating the application of the PA technique in arthritis. We are developing a CT-geometry version PA finger imager, intended for early clinical assessment of the method. The imager uses two curved array ultrasound detectors each with 64 elements with central frequencies 1.5 and 7.5 MHz respectively, stacked above each other. Both cover approximately 180 degrees of the circle. Illumination is provided with a multiple of optical fiber bundles coupled to a laser-OPO system. Ultrasound imaging is also possible with the system, since the curved arrays are each provided with 12 or 8 ultrasound pulsers. We have investigated systematically imaging of finger vasculature in healthy volunteers using an earlier laboratory prototype. In this paper we present finger imaging results of a patient diagnosed with rheumatoid arthritis.
KW - Aheumatoid arthritis
KW - Finger joint imaging
KW - Imaging of inflamed synovium
KW - Optoacoustic imaging
KW - Photoacoustic imaging
KW - Ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=85019521675&partnerID=8YFLogxK
U2 - 10.1117/12.2183633
DO - 10.1117/12.2183633
M3 - Conference contribution
SN - 9781628417012
VL - 9539
BT - Proceedings Opto-Acoustic Methods and Applications in Biophotonics II
A2 - Ntziachristos, Vasilis
A2 - Zemp, Roger
PB - SPIE
CY - Munich, Germany
T2 - European Conferences on Biomedical Optics, ECBO 2015
Y2 - 21 June 2015 through 25 June 2015
ER -