Coregistered Photoacoustic and ultrasound tomography of healthy and inflamed human interphalangeal joints

Peter van Es, R.C. Vlieg, Erwin Hondebrink, Johannes C.G. van Hespen, H.B. Moens, Wiendelt Steenbergen, Srirang Manohar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)


Photoacoustic (PA) or optoacoustic (OA) imaging combines the high (blood) contrast to light with the high-resolution of ultrasound. The method can visualize vascularization deep inside tissue. Of late there is interest in PA imaging of synovial joints which are expected to be associated with increased vascularization in the event of rheumatoid arthritis (RA). We here describe our approach in investigating the application of the PA technique in arthritis. We are developing a CT-geometry version PA finger imager, intended for early clinical assessment of the method. The imager uses two curved array ultrasound detectors each with 64 elements with central frequencies 1.5 and 7.5 MHz respectively, stacked above each other. Both cover approximately 180 degrees of the circle. Illumination is provided with a multiple of optical fiber bundles coupled to a laser-OPO system. Ultrasound imaging is also possible with the system, since the curved arrays are each provided with 12 or 8 ultrasound pulsers. We have investigated systematically imaging of finger vasculature in healthy volunteers using an earlier laboratory prototype. In this paper we present finger imaging results of a patient diagnosed with rheumatoid arthritis.

Original languageEnglish
Title of host publicationProceedings Opto-Acoustic Methods and Applications in Biophotonics II
EditorsVasilis Ntziachristos, Roger Zemp
Place of PublicationMunich, Germany
Number of pages6
ISBN (Print)9781628417012
Publication statusPublished - 21 Jun 2015
EventEuropean Conferences on Biomedical Optics, ECBO 2015 - ICM Munich, Munich, Germany
Duration: 21 Jun 201525 Jun 2015

Publication series

ISSN (Print)0277-786X


ConferenceEuropean Conferences on Biomedical Optics, ECBO 2015
Abbreviated titleECBO 2015


  • Aheumatoid arthritis
  • Finger joint imaging
  • Imaging of inflamed synovium
  • Optoacoustic imaging
  • Photoacoustic imaging
  • Ultrasound tomography


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