Correcting photoacoustic signals for fluence variations using acousto-optic modulation

Khalid Daoudi, Altaf Hussain, Erwin Hondebrink, Wiendelt Steenbergen

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)
52 Downloads (Pure)

Abstract

We present a theoretical concept which may lead to quantitative photoacoustic mapping of chromophore concentrations. The approach supposes a technique capable of tagging light in a well-defined tagging volume at a specific location deep in the medium. We derive a formula that expresses the local absorption coefficient inside a medium in terms of noninvasively measured quantities and experimental parameters and we validate the theory using Monte Carlo simulations. Furthermore, we performed an experiment to basically validate the concept as a strategy to correct for fluence variations in photoacoustics. In the experiment we exploit the possibility of acousto-optic modulation, using focused ultrasound, to tag photons. Results show that the variation in photoacoustic signals of absorbing insertions embedded at different depths in a phantom, caused by fluence variations of more than one order of magnitude, can be corrected for to an accuracy of 5%
Original languageEnglish
Pages (from-to)14117-14129
Number of pages13
JournalOptics express
Volume20
Issue number13
DOIs
Publication statusPublished - 2012

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