Cortical depth-dependent effects of thermal and physiological denoising in BOLD fMRI

M. Guidi; G. Giulietti; H. E. Möller; D. G. Norris; F. Giove

doi:10.1393/ncc/i2025-25230-y

Cortical depth-dependent effects of thermal and physiological denoising in BOLD fMRI

M. Guidi
, G. Giulietti
, H. E. Möller
, D. G. Norris
, F. Giove^*

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › Academic › peer-review

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Abstract

Functional magnetic resonance imaging (fMRI) at high resolution in the human brain can attribute signal changes to different cortical depths, and help characterize layer functional connectivity. The fMRI signal based on the blood-oxygen level dependent (BOLD) contrast is confounded by noise components of thermal and physiological origin. For sub-millimeter voxel size, the thermal noise dominates over physiological noise, but physiological noise is still present, especially in upper layers. In this work, we applied thermal and physiological denoising to a resting-state fMRI dataset acquired at 7 T and evaluated the depth-dependent changes in temporal signal-to-noise ratio and laminar functional connectivity.

Original language	English
Article number	230
Journal	Nuovo Cimento della Societa Italiana di Fisica C
Volume	48
Issue number	4
DOIs	https://doi.org/10.1393/ncc/i2025-25230-y
Publication status	Published - 2025
Externally published	Yes
Event	110th National Congress of the Italian Physical Society, SIF 2024 - Bologna, Italy Duration: 9 Sept 2024 → 13 Sept 2024 Conference number: 110

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title = "Cortical depth-dependent effects of thermal and physiological denoising in BOLD fMRI",

abstract = "Functional magnetic resonance imaging (fMRI) at high resolution in the human brain can attribute signal changes to different cortical depths, and help characterize layer functional connectivity. The fMRI signal based on the blood-oxygen level dependent (BOLD) contrast is confounded by noise components of thermal and physiological origin. For sub-millimeter voxel size, the thermal noise dominates over physiological noise, but physiological noise is still present, especially in upper layers. In this work, we applied thermal and physiological denoising to a resting-state fMRI dataset acquired at 7 T and evaluated the depth-dependent changes in temporal signal-to-noise ratio and laminar functional connectivity.",

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TY - JOUR

T1 - Cortical depth-dependent effects of thermal and physiological denoising in BOLD fMRI

AU - Guidi, M.

AU - Giulietti, G.

AU - Möller, H. E.

AU - Norris, D. G.

AU - Giove, F.

N1 - Conference code: 110

PY - 2025

Y1 - 2025

N2 - Functional magnetic resonance imaging (fMRI) at high resolution in the human brain can attribute signal changes to different cortical depths, and help characterize layer functional connectivity. The fMRI signal based on the blood-oxygen level dependent (BOLD) contrast is confounded by noise components of thermal and physiological origin. For sub-millimeter voxel size, the thermal noise dominates over physiological noise, but physiological noise is still present, especially in upper layers. In this work, we applied thermal and physiological denoising to a resting-state fMRI dataset acquired at 7 T and evaluated the depth-dependent changes in temporal signal-to-noise ratio and laminar functional connectivity.

AB - Functional magnetic resonance imaging (fMRI) at high resolution in the human brain can attribute signal changes to different cortical depths, and help characterize layer functional connectivity. The fMRI signal based on the blood-oxygen level dependent (BOLD) contrast is confounded by noise components of thermal and physiological origin. For sub-millimeter voxel size, the thermal noise dominates over physiological noise, but physiological noise is still present, especially in upper layers. In this work, we applied thermal and physiological denoising to a resting-state fMRI dataset acquired at 7 T and evaluated the depth-dependent changes in temporal signal-to-noise ratio and laminar functional connectivity.

UR - https://www.scopus.com/pages/publications/105018472817

U2 - 10.1393/ncc/i2025-25230-y

DO - 10.1393/ncc/i2025-25230-y

M3 - Conference article

AN - SCOPUS:105018472817

SN - 2037-4909

VL - 48

JO - Nuovo Cimento della Societa Italiana di Fisica C

JF - Nuovo Cimento della Societa Italiana di Fisica C

IS - 4

M1 - 230

T2 - 110th National Congress of the Italian Physical Society, SIF 2024

Y2 - 9 September 2024 through 13 September 2024

ER -

Cortical depth-dependent effects of thermal and physiological denoising in BOLD fMRI

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