Corticosteroid microvesicles for treatment of cardiovascular diseases

Zahi A. Fayad; Willem Jan Menno Mulder; Gerrit Storm,; Josbert Maarten Metselaar

Corticosteroid microvesicles for treatment of cardiovascular diseases

Zahi A. Fayad (Inventor)
, Willem Jan Menno Mulder (Inventor)
, Gerrit Storm, (Inventor)
, Josbert Maarten Metselaar (Inventor)

Biomaterials Science and Technology

Research output: Patent

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Abstract

The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle- forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided.

Original language	English
Patent number	WO2009146303
IPC	C07C 5/ 00 A I
Priority date	26/05/08
Publication status	Published - 3 Dec 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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WO2009146303A1Final published version, 2.51 MB

https://patents.google.com/patent/WO2009146303A1/en

Cite this

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title = "Corticosteroid microvesicles for treatment of cardiovascular diseases",

abstract = "The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle- forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided.",

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T1 - Corticosteroid microvesicles for treatment of cardiovascular diseases

AU - Fayad, Zahi A.

AU - Mulder, Willem Jan Menno

AU - Storm,, Gerrit

AU - Metselaar, Josbert Maarten

PY - 2009/12/3

Y1 - 2009/12/3

N2 - The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle- forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided.

AB - The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle- forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided.

M3 - Patent

M1 - WO2009146303

ER -

Corticosteroid microvesicles for treatment of cardiovascular diseases

Abstract

UN SDGs

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