Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 65-74 |
| Number of pages | 10 |
| Journal | Alzheimer's & dementia |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Sep 2016 |
Fingerprint
Keywords
- METIS-313016
- IR-98674
Cite this
}
Could ecosystem management provide a new framework for Alzheimer's disease? / Hubin, E.; Vanschoenwinkel, B.; Broersen, Kerensa; de Deyn, P.P.; Koedam, N.; van Nuland, N.; Pauwels, K.
In: Alzheimer's & dementia, Vol. 12, No. 1, 01.09.2016, p. 65-74.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Could ecosystem management provide a new framework for Alzheimer's disease?
AU - Hubin, E.
AU - Vanschoenwinkel, B.
AU - Broersen, Kerensa
AU - de Deyn, P.P.
AU - Koedam, N.
AU - van Nuland, N.
AU - Pauwels, K.
N1 - In Press, Corrected Proof
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that involves a plethora of molecular pathways. In the context of therapeutic treatment and biomarker profiling, the amyloid-beta (Aβ) peptide constitutes an interesting research avenue that involves interactions within a complex mixture of Aβ alloforms and other disease-modifying factors. Here, we explore the potential of an ecosystem paradigm as a novel way to consider AD and Aβ dynamics in particular. We discuss the example that the complexity of the Aβ network not only exhibits interesting parallels with the functioning of complex systems such as ecosystems but that this analogy can also provide novel insights into the neurobiological phenomena in AD and serve as a communication tool. We propose that combining network medicine with general ecosystem management principles could be a new and holistic approach to understand AD pathology and design novel therapies.
AB - Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that involves a plethora of molecular pathways. In the context of therapeutic treatment and biomarker profiling, the amyloid-beta (Aβ) peptide constitutes an interesting research avenue that involves interactions within a complex mixture of Aβ alloforms and other disease-modifying factors. Here, we explore the potential of an ecosystem paradigm as a novel way to consider AD and Aβ dynamics in particular. We discuss the example that the complexity of the Aβ network not only exhibits interesting parallels with the functioning of complex systems such as ecosystems but that this analogy can also provide novel insights into the neurobiological phenomena in AD and serve as a communication tool. We propose that combining network medicine with general ecosystem management principles could be a new and holistic approach to understand AD pathology and design novel therapies.
KW - METIS-313016
KW - IR-98674
U2 - 10.1016/j.jalz.2015.07.491
DO - 10.1016/j.jalz.2015.07.491
M3 - Article
VL - 12
SP - 65
EP - 74
JO - Alzheimer's & dementia
JF - Alzheimer's & dementia
SN - 1552-5260
IS - 1
ER -