Covalent Coupling of Nanoparticles with Low-Density Functional Ligands to Surfaces via Click Chemistry

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Abstract

We demonstrate the application of the 1,3-dipolar cycloaddition (“click‿ reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1–2 chemical bonds are formed between the particles and the substrate.
Original languageUndefined
Pages (from-to)3705-3717
Number of pages13
JournalInternational journal of molecular sciences
Volume14
Issue number2
DOIs
Publication statusPublished - 7 Feb 2013

Keywords

  • EWI-24406
  • IR-89202
  • METIS-301584

Cite this

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title = "Covalent Coupling of Nanoparticles with Low-Density Functional Ligands to Surfaces via Click Chemistry",
abstract = "We demonstrate the application of the 1,3-dipolar cycloaddition (“click‿ reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1–2 chemical bonds are formed between the particles and the substrate.",
keywords = "EWI-24406, IR-89202, METIS-301584",
author = "I. Rianasari and {de Jong}, {Machiel Pieter} and Jurriaan Huskens and {van der Wiel}, {Wilfred Gerard}",
year = "2013",
month = "2",
day = "7",
doi = "10.3390/ijms14023705",
language = "Undefined",
volume = "14",
pages = "3705--3717",
journal = "International journal of molecular sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "2",

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TY - JOUR

T1 - Covalent Coupling of Nanoparticles with Low-Density Functional Ligands to Surfaces via Click Chemistry

AU - Rianasari, I.

AU - de Jong, Machiel Pieter

AU - Huskens, Jurriaan

AU - van der Wiel, Wilfred Gerard

PY - 2013/2/7

Y1 - 2013/2/7

N2 - We demonstrate the application of the 1,3-dipolar cycloaddition (“click‿ reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1–2 chemical bonds are formed between the particles and the substrate.

AB - We demonstrate the application of the 1,3-dipolar cycloaddition (“click‿ reaction) to couple gold nanoparticles (Au NPs) functionalized with low densities of functional ligands. The ligand coverage on the citrate-stabilized Au NPs was adjusted by the ligand:Au surface atom ratio, while maintaining the colloidal stability of the Au NPs in aqueous solution. A procedure was developed to determine the driving forces governing the selectivity and reactivity of citrate-stabilized and ligand-functionalized Au NPs on patterned self-assembled monolayers. We observed selective and remarkably stable chemical bonding of the Au NPs to the complimentarily functionalized substrate areas, even when estimating that only 1–2 chemical bonds are formed between the particles and the substrate.

KW - EWI-24406

KW - IR-89202

KW - METIS-301584

U2 - 10.3390/ijms14023705

DO - 10.3390/ijms14023705

M3 - Article

VL - 14

SP - 3705

EP - 3717

JO - International journal of molecular sciences

JF - International journal of molecular sciences

SN - 1661-6596

IS - 2

ER -