Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering

Michel Klein Gunnewiek, Andrea Di Luca, Hermannes Z. Bollemaat, Clemens van Blitterswijk, Gyula J. Vancso, Lorenzo Moroni, Edmondo Maria Benetti

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)


Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments
Original languageUndefined
Pages (from-to)1169-1174
JournalAdvanced healthcare materials
Issue number8
Publication statusPublished - 2015


  • IR-99897
  • METIS-314681

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