Critical evaluation of the computational methods used in the forced polymer translocation

V.V. Lehtola, R.P. Linna, K. Kaski

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Abstract

n forced polymer translocation, the average translocation time τ scales with respect to pore force f and polymer length N as τ∼f−1Nβ. We demonstrate that an artifact in the Metropolis Monte Carlo method resulting in breakage of the force scaling with large f may be responsible for some of the controversies between different computationally obtained results and also between computational and experimental results. Using Langevin dynamics simulations we show that the scaling exponent β⩽1+ν is not universal, but depends on f. Moreover, we show that forced translocation can be described by a relatively simple force balance argument and β to arise solely from the initial polymer configuration.
Original languageEnglish
Article number061803
Pages (from-to)1-8
Number of pages8
JournalPhysical Review E
Volume78
DOIs
Publication statusPublished - 29 Dec 2008
Externally publishedYes

Keywords

  • Biomembrane transport
  • Differential equations
  • Molecular biophysics
  • Monte Carlo methods
  • Nonlinear dynamical systems
  • Polymers
  • Stochastic processes
  • ITC-ISI-JOURNAL-ARTICLE
  • n/a OA procedure

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