Critical evaluation of the computational methods used in the forced polymer translocation

V. V. Lehtola, R. P. Linna, K. Kaski

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)


n forced polymer translocation, the average translocation time τ scales with respect to pore force f and polymer length N as τ∼f−1Nβ. We demonstrate that an artifact in the Metropolis Monte Carlo method resulting in breakage of the force scaling with large f may be responsible for some of the controversies between different computationally obtained results and also between computational and experimental results. Using Langevin dynamics simulations we show that the scaling exponent β⩽1+ν is not universal, but depends on f. Moreover, we show that forced translocation can be described by a relatively simple force balance argument and β to arise solely from the initial polymer configuration.
Original languageEnglish
Article number061803
Pages (from-to)1-8
Number of pages8
JournalPhysical Review E
Publication statusPublished - 29 Dec 2008
Externally publishedYes


  • biomembrane transport
  • differential equations
  • molecular biophysics
  • Monte Carlo methods
  • nonlinear dynamical systems
  • polymers
  • stochastic processes


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