Abstract
| Original language | English |
|---|---|
| Article number | 061803 |
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Physical Review E |
| Volume | 78 |
| DOIs | |
| Publication status | Published - 29 Dec 2008 |
| Externally published | Yes |
Keywords
- biomembrane transport
- differential equations
- molecular biophysics
- Monte Carlo methods
- nonlinear dynamical systems
- polymers
- stochastic processes
- ITC-ISI-JOURNAL-ARTICLE
Cite this
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Critical evaluation of the computational methods used in the forced polymer translocation. / Lehtola, V. V.; Linna, R. P.; Kaski, K.
In: Physical Review E, Vol. 78, 061803, 29.12.2008, p. 1-8.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Critical evaluation of the computational methods used in the forced polymer translocation
AU - Lehtola, V. V.
AU - Linna, R. P.
AU - Kaski, K.
PY - 2008/12/29
Y1 - 2008/12/29
N2 - n forced polymer translocation, the average translocation time τ scales with respect to pore force f and polymer length N as τ∼f−1Nβ. We demonstrate that an artifact in the Metropolis Monte Carlo method resulting in breakage of the force scaling with large f may be responsible for some of the controversies between different computationally obtained results and also between computational and experimental results. Using Langevin dynamics simulations we show that the scaling exponent β⩽1+ν is not universal, but depends on f. Moreover, we show that forced translocation can be described by a relatively simple force balance argument and β to arise solely from the initial polymer configuration.
AB - n forced polymer translocation, the average translocation time τ scales with respect to pore force f and polymer length N as τ∼f−1Nβ. We demonstrate that an artifact in the Metropolis Monte Carlo method resulting in breakage of the force scaling with large f may be responsible for some of the controversies between different computationally obtained results and also between computational and experimental results. Using Langevin dynamics simulations we show that the scaling exponent β⩽1+ν is not universal, but depends on f. Moreover, we show that forced translocation can be described by a relatively simple force balance argument and β to arise solely from the initial polymer configuration.
KW - biomembrane transport
KW - differential equations
KW - molecular biophysics
KW - Monte Carlo methods
KW - nonlinear dynamical systems
KW - polymers
KW - stochastic processes
KW - ITC-ISI-JOURNAL-ARTICLE
UR - https://ezproxy2.utwente.nl/login?url=https://doi.org/10.1103/PhysRevE.78.061803
UR - https://ezproxy2.utwente.nl/login?url=https://library.itc.utwente.nl/login/2008/isi/lehtola_cri.pdf
U2 - 10.1103/PhysRevE.78.061803
DO - 10.1103/PhysRevE.78.061803
M3 - Article
VL - 78
SP - 1
EP - 8
JO - Physical review E: covering statistical, nonlinear, biological, and soft matter physics
JF - Physical review E: covering statistical, nonlinear, biological, and soft matter physics
SN - 2470-0045
M1 - 061803
ER -