Abstract
The application of agarose in hemoperfusion is hampered by the lack of a suitable sterilization method. A technique has been developed for the crosslinking of agarose encapsulated sorbents by the reaction with 1,3-dichloro-2-propanol (DCP) under strong alkaline conditions. A twofold molar excess of DCP with respect to agarose and an equimolar amount of sodium hydroxide at a concentration of 0.3 mol/L with a reaction time of 1-4 h at 50°C are found to be the optimal conditions. The compressive strength of crosslinked beads is increased by a factor of 4. Agarose capsules are found to degrade by the influence of Y radiation, but are resistant to steam sterilization at 134°C during at least 30 min when crosslinked.
| Original language | English |
|---|---|
| Pages (from-to) | 1-13 |
| Journal | Journal of biomedical materials research |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1983 |
Keywords
- IR-70739
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de Koning, H. W. M., Chamuleau, R. A. F. M., & Bantjes, A. (1983). Crosslinked agarose encapsulated sorbents resistant to steam sterilization. Preparation and mechanical properties. Journal of biomedical materials research, 18(1), 1-13. https://doi.org/10.1002/jbm.820180103