Crosslinked agarose encapsulated sorbents resistant to steam sterilization. Preparation and mechanical properties

Henk W.M. de Koning, Rob A.F.M. Chamuleau, Adriaan Bantjes

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    Abstract

    The application of agarose in hemoperfusion is hampered by the lack of a suitable sterilization method. A technique has been developed for the crosslinking of agarose encapsulated sorbents by the reaction with 1,3-dichloro-2-propanol (DCP) under strong alkaline conditions. A twofold molar excess of DCP with respect to agarose and an equimolar amount of sodium hydroxide at a concentration of 0.3 mol/L with a reaction time of 1-4 h at 50°C are found to be the optimal conditions. The compressive strength of crosslinked beads is increased by a factor of 4. Agarose capsules are found to degrade by the influence of Y radiation, but are resistant to steam sterilization at 134°C during at least 30 min when crosslinked.
    Original languageEnglish
    Pages (from-to)1-13
    JournalJournal of biomedical materials research
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 1983

    Keywords

    • IR-70739

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