The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a clear and micellar crosslinking solution and to promote the penetration of HMDIC in the DSC matrix. Using optimized conditions treatment of non-crosslinked DSC (N-DSC) with HMDIC (H-DSC) increased the shrinkage temperature (Ts) of N-DSC from 56°C to 74°C for H-DSC. A linear relation between the decrease in free amine group content and the increase in Ts was observed. Crosslinking with HMDIC did not influence the tensile strength of the N-DSC samples but increased the elongation at break from 141% to 163% and decreased the high-strain modulus from 26 MPa to 16 MPa for the H-DSC samples, respectively.
|Journal||Journal of materials science. Materials in medicine|
|Publication status||Published - 1995|
Olde damink, L. H. H., Dijkstra, P. J., van Luyn, M. J. A., van Wachem, P. B., Nieuwenhuis, P., & Feijen, J. (1995). Crosslinking of dermal sheep collagen using hexamethylene diisocyanate. Journal of materials science. Materials in medicine, 6(7), 429-434. https://doi.org/10.1007/BF00120286