Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 429-434 |
| Journal | Journal of materials science. Materials in medicine |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- METIS-105354
- IR-85773
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Crosslinking of dermal sheep collagen using hexamethylene diisocyanate. / Olde damink, L.H.H.; Dijkstra, P.J.; van Luyn, M.J.A.; van Wachem, P.B.; Nieuwenhuis, P.; Feijen, J.
In: Journal of materials science. Materials in medicine, Vol. 6, No. 7, 1995, p. 429-434.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Crosslinking of dermal sheep collagen using hexamethylene diisocyanate
AU - Olde damink, L.H.H.
AU - Dijkstra, P.J.
AU - van Luyn, M.J.A.
AU - van Wachem, P.B.
AU - Nieuwenhuis, P.
AU - Feijen, J.
PY - 1995
Y1 - 1995
N2 - The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a clear and micellar crosslinking solution and to promote the penetration of HMDIC in the DSC matrix. Using optimized conditions treatment of non-crosslinked DSC (N-DSC) with HMDIC (H-DSC) increased the shrinkage temperature (Ts) of N-DSC from 56°C to 74°C for H-DSC. A linear relation between the decrease in free amine group content and the increase in Ts was observed. Crosslinking with HMDIC did not influence the tensile strength of the N-DSC samples but increased the elongation at break from 141% to 163% and decreased the high-strain modulus from 26 MPa to 16 MPa for the H-DSC samples, respectively.
AB - The use of hexamethylene diisocyanate (HMDIC) as a crosslinking agent for dermal sheep collagen (DSC) was studied. Because HMDIC is only slightly water soluble, a surfactant was used to obtain a clear and micellar crosslinking solution and to promote the penetration of HMDIC in the DSC matrix. Using optimized conditions treatment of non-crosslinked DSC (N-DSC) with HMDIC (H-DSC) increased the shrinkage temperature (Ts) of N-DSC from 56°C to 74°C for H-DSC. A linear relation between the decrease in free amine group content and the increase in Ts was observed. Crosslinking with HMDIC did not influence the tensile strength of the N-DSC samples but increased the elongation at break from 141% to 163% and decreased the high-strain modulus from 26 MPa to 16 MPa for the H-DSC samples, respectively.
KW - METIS-105354
KW - IR-85773
U2 - 10.1007/BF00120286
DO - 10.1007/BF00120286
M3 - Article
VL - 6
SP - 429
EP - 434
JO - Journal of materials science. Materials in medicine
JF - Journal of materials science. Materials in medicine
SN - 0957-4530
IS - 7
ER -