Crosslinking of porcine aortic leaflets with butane-1,4-diol diglycidyl ether

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Currently, efforts are being made to reduce xenograft calcification and to optimize biomechanical properties by applying different crosslinking methods and techniques. Porcine aortic leaflets could be stabilized with a bisepoxy compound, butane-1,4-diol diglycidyl ether (BDDGE), under acidic (pH 4.5) or alkaline conditions (pH > 8.5). Maximum values of the shrinkage temperature (83°C), which are comparable to glutaraldehyde-crosslinked materials, are achieved at pH 9.0 and 10.0 within 48 h with a BDDGE concentration of 4 wt6percnt;. The crosslinking efficacy decreased at higher pH values or at prolonged reaction times due to a higher proportion of one-side or masking reactions. Crosslinking of aortic leaflets at pH 4.5, which consisted in a reaction between the epoxide groups of BDDGE and the carboxylic acid groups of the tissue, afforded crosslinked material with a shrinkage temperature of 76°C after 7 days of reaction.
Original languageUndefined
Title of host publicationPolymers in medicine
EditorsJ. dr. Kahovec, I. Meisel, C.S. Kniep, S. Spiegel
Place of PublicationWeinheim
PublisherWiley-VCH Verlag
ISBN (Print)3-527-30 334-0
Publication statusPublished - 17 Jul 2001

Publication series

PublisherInternational Union of Pure and Applied Chemistry
ISSN (Print)1022-1360
ISSN (Electronic)1521-3900


  • IR-71675
  • METIS-205204

Cite this

Dijkstra, P. J., Zeeman, R., & Feijen, J. (2001). Crosslinking of porcine aortic leaflets with butane-1,4-diol diglycidyl ether. In J. dr. Kahovec, I. Meisel, C. S. Kniep, & S. Spiegel (Eds.), Polymers in medicine (pp. 11-20). Weinheim: Wiley-VCH Verlag.<11::AID-MASY11>3.0.CO;2-E