Crosslinking of porcine aortic leaflets with butane-1,4-diol diglycidyl ether

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Downloads (Pure)

Abstract

Currently, efforts are being made to reduce xenograft calcification and to optimize biomechanical properties by applying different crosslinking methods and techniques. Porcine aortic leaflets could be stabilized with a bisepoxy compound, butane-1,4-diol diglycidyl ether (BDDGE), under acidic (pH 4.5) or alkaline conditions (pH > 8.5). Maximum values of the shrinkage temperature (83°C), which are comparable to glutaraldehyde-crosslinked materials, are achieved at pH 9.0 and 10.0 within 48 h with a BDDGE concentration of 4 wt6percnt;. The crosslinking efficacy decreased at higher pH values or at prolonged reaction times due to a higher proportion of one-side or masking reactions. Crosslinking of aortic leaflets at pH 4.5, which consisted in a reaction between the epoxide groups of BDDGE and the carboxylic acid groups of the tissue, afforded crosslinked material with a shrinkage temperature of 76°C after 7 days of reaction.
Original languageUndefined
Title of host publicationPolymers in medicine
EditorsJ. dr. Kahovec, I. Meisel, C.S. Kniep, S. Spiegel
Place of PublicationWeinheim
PublisherWiley-VCH Verlag
Pages11-20
ISBN (Print)3-527-30 334-0
DOIs
Publication statusPublished - 17 Jul 2001
Event40th Microsymposium of the Prague Meetings on Macrmolecules: Polymers in medicine - Weinheim
Duration: 17 Jul 200020 Jul 2000

Publication series

Name
PublisherInternational Union of Pure and Applied Chemistry
Number1
Volume172
ISSN (Print)1022-1360
ISSN (Electronic)1521-3900

Conference

Conference40th Microsymposium of the Prague Meetings on Macrmolecules
CityWeinheim
Period17/07/0020/07/00

Keywords

  • IR-71675
  • METIS-205204

Cite this