Crown ethers can enhance enzyme activity in organic solvents

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Abstract

The effect of various crown ethers on the transesterification reaction of N-acetyl(L)phenylalanine ethyl ester with propanol catalyzed by α-chymotrypsin was investigated. Crown ethers can strongly enhance this reaction in different organic solvents. A macrocyclic effect is responsible for the increased enzymatic activity. Several possible crown ether enzyme interactions are discussed.
Original languageEnglish
Title of host publicationBiocatalysis in non-conventional media
EditorsJ. Tramper, M.H. Vermüe, H.H. Beeftink, U. von Stockar
Place of PublicationAmsterdam
PublisherElsevier
Pages691-695
Number of pages5
ISBN (Print)9780444890467
DOIs
Publication statusPublished - 1992
EventInternational Symposium on Biocatalysis in Non-Conventional Media 1992 - Noordwijkerhout, Netherlands
Duration: 26 Apr 199229 Apr 1992

Publication series

NameProgress in Biotechnology
PublisherElsevier
Volume8

Conference

ConferenceInternational Symposium on Biocatalysis in Non-Conventional Media 1992
CountryNetherlands
CityNoordwijkerhout
Period26/04/9229/04/92

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Broos, J., Verboom, W., Engbersen, J. F. J., & Reinhoudt, D. N. (1992). Crown ethers can enhance enzyme activity in organic solvents. In J. Tramper, M. H. Vermüe, H. H. Beeftink, & U. von Stockar (Eds.), Biocatalysis in non-conventional media (pp. 691-695). (Progress in Biotechnology; Vol. 8). Amsterdam: Elsevier. https://doi.org/10.1016/B978-0-444-89046-7.50099-0