Cultured neural networks: optimisation of patterned network adhesiveness and characterization of their neural activity

Wim Rutten, T.G. Ruardij, G.W. van Staveren, Enrico Marani, B.H. Roelofsen

    Research output: Contribution to conferencePaper

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    Abstract

    A 'cultured probe' is a hybrid type of neural information transducer or prosthesis, for stimulation and/or recording of neural activity in the brain or the spinal (ventral motor region or dorsal sensory region). It consists of a micro electrode array (MEA) on a planar substrate, each electrode being covered and surrounded by a local circularly confined network ('island') of cultured neurons, obtained by chemical patterning of the substrate. The purpose of the local networks of cultured cells is that they act as intermediates for collateral sprouts from the in vivo system, thus allowing for an effective and selective neuron electrode interface. As the local neural network of cortical neurons can also become spontaneously active and therefore has the principal capability of information processing, one may even envisage future applications of these intermediary networks as 'front-end' signal processors.
    Original languageEnglish
    Number of pages1
    Publication statusPublished - 2005
    Event7th International Conference on Cellular Engineering, ICCE 2005 - Seoul, Korea, Republic of
    Duration: 6 Sep 20059 Sep 2005
    Conference number: 7

    Conference

    Conference7th International Conference on Cellular Engineering, ICCE 2005
    Abbreviated titleICCE
    CountryKorea, Republic of
    CitySeoul
    Period6/09/059/09/05

    Keywords

    • network patterning
    • EWI-19936
    • Synchronization
    • network activity
    • neurophilic/neurophobic substrate coating
    • MEA
    • Neural Networks
    • IR-76578

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    Rutten, W., Ruardij, T. G., van Staveren, G. W., Marani, E., & Roelofsen, B. H. (2005). Cultured neural networks: optimisation of patterned network adhesiveness and characterization of their neural activity. Paper presented at 7th International Conference on Cellular Engineering, ICCE 2005, Seoul, Korea, Republic of.