Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.
|Title of host publication||4th Dutch Conference on Bio-Medical Engineering|
|Number of pages||1|
|ISBN (Print)||not assigned|
|Publication status||Published - 2013|
|Event||4th Dutch Bio-Medical Engineering Conference, BME 2013 - Hotel Zuiderduin, Egmond aan Zee, Netherlands|
Duration: 24 Jan 2013 → 25 Jan 2013
Conference number: 4
|Conference||4th Dutch Bio-Medical Engineering Conference, BME 2013|
|City||Egmond aan Zee|
|Period||24/01/13 → 25/01/13|
|Other||Fourth Dutch BME Conference|
van Dijk, K. J., Zwartjes - de Klerk, D. G. M., Janssen, M. L. F., Benazzouz, A., Temel, Y., Visser-Vandewalle, V., ... Veltink, P. H. (2013). Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. In 4th Dutch Conference on Bio-Medical Engineering (pp. 1). BME.