Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

Kees Joab van Dijk; D.G.M Zwartjes - de Klerk; M.L.F Janssen; A. Benazzouz; Y. Temel; V. Visser-Vandewalle; Tjitske Heida; Petrus H. Veltink

Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

Kees Joab van Dijk, D.G.M Zwartjes - de Klerk, M.L.F Janssen, A. Benazzouz, Y. Temel, V. Visser-Vandewalle, Tjitske Heida, Petrus H. Veltink

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.

Original language	English
Title of host publication	4th Dutch Conference on Bio-Medical Engineering
Publisher	BME
Pages	1
Number of pages	1
ISBN (Print)	not assigned
Publication status	Published - 2013
Event	4th Dutch Bio-Medical Engineering Conference, BME 2013 - Hotel Zuiderduin, Egmond aan Zee, Netherlands Duration: 24 Jan 2013 → 25 Jan 2013 Conference number: 4 http://www.bme2013.nl/

Publication series

Name
Publisher	BME

Conference

Conference	4th Dutch Bio-Medical Engineering Conference, BME 2013
Abbreviated title	BME
Country	Netherlands
City	Egmond aan Zee
Period	24/01/13 → 25/01/13
Other	Fourth Dutch BME Conference
Internet address	http://www.bme2013.nl/

Keywords

EWI-24318
IR-89414
METIS-302649

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http://eprints.eemcs.utwente.nl/secure2/24318/01/Van_Dijk_Dutch_BME_Conference_2013.pdf

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van Dijk, K. J., Zwartjes - de Klerk, D. G. M., Janssen, M. L. F., Benazzouz, A., Temel, Y., Visser-Vandewalle, V., Heida, T., & Veltink, P. H. (2013). Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. In 4th Dutch Conference on Bio-Medical Engineering (pp. 1). BME. http://eprints.eemcs.utwente.nl/secure2/24318/01/Van_Dijk_Dutch_BME_Conference_2013.pdf

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title = "Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus",

abstract = "Parkinson{\textquoteright}s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson{\textquoteright}s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.",

keywords = "EWI-24318, IR-89414, METIS-302649",

author = "{van Dijk}, {Kees Joab} and {Zwartjes - de Klerk}, D.G.M and M.L.F Janssen and A. Benazzouz and Y. Temel and V. Visser-Vandewalle and Tjitske Heida and Veltink, {Petrus H.}",

year = "2013",

language = "English",

isbn = "not assigned",

publisher = "BME",

pages = "1",

booktitle = "4th Dutch Conference on Bio-Medical Engineering",

note = "4th Dutch Bio-Medical Engineering Conference, BME 2013, BME ; Conference date: 24-01-2013 Through 25-01-2013",

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van Dijk, KJ, Zwartjes - de Klerk, DGM, Janssen, MLF, Benazzouz, A, Temel, Y, Visser-Vandewalle, V, Heida, T & Veltink, PH 2013, Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. in 4th Dutch Conference on Bio-Medical Engineering. BME, pp. 1, 4th Dutch Bio-Medical Engineering Conference, BME 2013, Egmond aan Zee, Netherlands, 24/01/13. <http://eprints.eemcs.utwente.nl/secure2/24318/01/Van_Dijk_Dutch_BME_Conference_2013.pdf>

Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. / van Dijk, Kees Joab; Zwartjes - de Klerk, D.G.M; Janssen, M.L.F; Benazzouz, A.; Temel, Y.; Visser-Vandewalle, V.; Heida, Tjitske ; Veltink, Petrus H.

4th Dutch Conference on Bio-Medical Engineering. BME, 2013. p. 1.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

AU - van Dijk, Kees Joab

AU - Zwartjes - de Klerk, D.G.M

AU - Janssen, M.L.F

AU - Benazzouz, A.

AU - Temel, Y.

AU - Visser-Vandewalle, V.

AU - Heida, Tjitske

AU - Veltink, Petrus H.

N1 - Conference code: 4

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N2 - Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.

AB - Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.

KW - EWI-24318

KW - IR-89414

KW - METIS-302649

M3 - Conference contribution

SN - not assigned

SP - 1

BT - 4th Dutch Conference on Bio-Medical Engineering

PB - BME

T2 - 4th Dutch Bio-Medical Engineering Conference, BME 2013

Y2 - 24 January 2013 through 25 January 2013

ER -