Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

Kees Joab van Dijk, D.G.M Zwartjes - de Klerk, M.L.F Janssen, A. Benazzouz, Y. Temel, V. Visser-Vandewalle, Tjitske Heida, Petrus H. Veltink

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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Abstract

Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.
Original languageEnglish
Title of host publication4th Dutch Conference on Bio-Medical Engineering
PublisherBME
Pages1
Number of pages1
ISBN (Print)not assigned
Publication statusPublished - 2013
Event4th Dutch Bio-Medical Engineering Conference, BME 2013 - Hotel Zuiderduin, Egmond aan Zee, Netherlands
Duration: 24 Jan 201325 Jan 2013
Conference number: 4
http://www.bme2013.nl/

Publication series

Name
PublisherBME

Conference

Conference4th Dutch Bio-Medical Engineering Conference, BME 2013
Abbreviated titleBME
CountryNetherlands
CityEgmond aan Zee
Period24/01/1325/01/13
OtherFourth Dutch BME Conference
Internet address

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Subthalamic Nucleus
Evoked Potentials
Deep Brain Stimulation
Parkinson Disease
Motor Cortex
Neurodegenerative Diseases
Therapeutics

Keywords

  • EWI-24318
  • IR-89414
  • METIS-302649

Cite this

van Dijk, K. J., Zwartjes - de Klerk, D. G. M., Janssen, M. L. F., Benazzouz, A., Temel, Y., Visser-Vandewalle, V., ... Veltink, P. H. (2013). Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. In 4th Dutch Conference on Bio-Medical Engineering (pp. 1). BME.
van Dijk, Kees Joab ; Zwartjes - de Klerk, D.G.M ; Janssen, M.L.F ; Benazzouz, A. ; Temel, Y. ; Visser-Vandewalle, V. ; Heida, Tjitske ; Veltink, Petrus H. / Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. 4th Dutch Conference on Bio-Medical Engineering. BME, 2013. pp. 1
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title = "Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus",
abstract = "Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.",
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van Dijk, KJ, Zwartjes - de Klerk, DGM, Janssen, MLF, Benazzouz, A, Temel, Y, Visser-Vandewalle, V, Heida, T & Veltink, PH 2013, Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. in 4th Dutch Conference on Bio-Medical Engineering. BME, pp. 1, 4th Dutch Bio-Medical Engineering Conference, BME 2013, Egmond aan Zee, Netherlands, 24/01/13.

Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. / van Dijk, Kees Joab; Zwartjes - de Klerk, D.G.M; Janssen, M.L.F; Benazzouz, A.; Temel, Y.; Visser-Vandewalle, V.; Heida, Tjitske; Veltink, Petrus H.

4th Dutch Conference on Bio-Medical Engineering. BME, 2013. p. 1.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

TY - GEN

T1 - Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

AU - van Dijk, Kees Joab

AU - Zwartjes - de Klerk, D.G.M

AU - Janssen, M.L.F

AU - Benazzouz, A.

AU - Temel, Y.

AU - Visser-Vandewalle, V.

AU - Heida, Tjitske

AU - Veltink, Petrus H.

PY - 2013

Y1 - 2013

N2 - Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.

AB - Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.

KW - EWI-24318

KW - IR-89414

KW - METIS-302649

M3 - Conference contribution

SN - not assigned

SP - 1

BT - 4th Dutch Conference on Bio-Medical Engineering

PB - BME

ER -

van Dijk KJ, Zwartjes - de Klerk DGM, Janssen MLF, Benazzouz A, Temel Y, Visser-Vandewalle V et al. Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus. In 4th Dutch Conference on Bio-Medical Engineering. BME. 2013. p. 1