Current source density analysis of cortically evoked potentials in the rat subthalamic nucleus

Kees Joab van Dijk, D.G.M Zwartjes - de Klerk, M.L.F Janssen, A. Benazzouz, Y. Temel, V. Visser-Vandewalle, Tjitske Heida, Petrus H. Veltink

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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    Abstract

    Parkinson’s disease is an age-related neurodegenerative disorder and is characterized by gradual deterioration of motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now widely used in neurosurgical therapy, because it markedly improves the Parkinson’s disease symptoms. Tracing studies have shown that the STN is segregated into multiple functional areas. We hypothesize that DBS should be targeted in the area responsible for motor function to reduce unwanted side effects and improve the positive DBS effects. Therefore, we are interested in localization of the functional areas of the STN. In our study, we determine the functional distribution of the synaptic inputs within the STN of anesthetized rats.
    Original languageEnglish
    Title of host publication4th Dutch Conference on Bio-Medical Engineering
    PublisherBME
    Pages1
    Number of pages1
    ISBN (Print)not assigned
    Publication statusPublished - 2013
    Event4th Dutch Bio-Medical Engineering Conference, BME 2013 - Hotel Zuiderduin, Egmond aan Zee, Netherlands
    Duration: 24 Jan 201325 Jan 2013
    Conference number: 4
    http://www.bme2013.nl/

    Publication series

    Name
    PublisherBME

    Conference

    Conference4th Dutch Bio-Medical Engineering Conference, BME 2013
    Abbreviated titleBME
    CountryNetherlands
    CityEgmond aan Zee
    Period24/01/1325/01/13
    OtherFourth Dutch BME Conference
    Internet address

    Keywords

    • EWI-24318
    • IR-89414
    • METIS-302649

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