Current status of treatment for diverticulitis

Bryan Joost Marinus van de Wall

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

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Abstract

Diverticula are outpouchings that occur at week points in the colonic wall where small blood vessels enter the circular muscle layer. Diverticula are most frequently found in the distal part of the colon, with 90% of patients having the sigmoid colon involved. Most patients who have diverticulosis remain asymptomatic; however an estimated 15-20% will develop diverticulitis. Acute diverticulitis is a complication of diverticulosis that occurs when these outpouchings become infected. It is theorised that inflammation occurs when the entrance to the diverticulum is obstructed by faecal matter leading to bacterial overgrowth and partial necrosis of the diverticular wall. To date, consensus appears to be lacking on several aspects regarding the diagnostic approach and treatment of diverticulitis. This has led to a joint Dutch initiative, the Dutch Diverticular Disease Collaborative Study Group. This study group is a cooperation of the Academic Medical Center Amsterdam, Erasmus Medical Center Rotterdam, Kennemer Hospital Haarlem, Meander Medical Center Amersfoort, Saint Lucas Andreas Hospital Amsterdam aiming to deliver evidence in the form of both retrospective and prospective studies to end these persisting controversies.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Broeders, Ivo Adriaan Maria Johannes, Supervisor
  • Consten, Esther C.J., Advisor, External person
  • Draaisma, Werner A., Advisor, External person
Thesis sponsors
Award date11 Apr 2013
Place of PublicationEnschede
Publisher
Print ISBNs978-94-6108-426-2
Publication statusPublished - 11 Apr 2013

Fingerprint

Diverticulitis
Diverticulum
Therapeutics
Sigmoid Colon
Blood Vessels
Colon
Necrosis
Retrospective Studies
Joints
Prospective Studies
Inflammation
Muscles

Keywords

  • EWI-24636
  • METIS-303015
  • Diverticulitis
  • IR-90457

Cite this

van de Wall, B. J. M. (2013). Current status of treatment for diverticulitis. Enschede: Universiteit Twente.
van de Wall, Bryan Joost Marinus. / Current status of treatment for diverticulitis. Enschede : Universiteit Twente, 2013. 164 p.
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van de Wall, BJM 2013, 'Current status of treatment for diverticulitis', University of Twente, Enschede.

Current status of treatment for diverticulitis. / van de Wall, Bryan Joost Marinus.

Enschede : Universiteit Twente, 2013. 164 p.

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

TY - THES

T1 - Current status of treatment for diverticulitis

AU - van de Wall, Bryan Joost Marinus

PY - 2013/4/11

Y1 - 2013/4/11

N2 - Diverticula are outpouchings that occur at week points in the colonic wall where small blood vessels enter the circular muscle layer. Diverticula are most frequently found in the distal part of the colon, with 90% of patients having the sigmoid colon involved. Most patients who have diverticulosis remain asymptomatic; however an estimated 15-20% will develop diverticulitis. Acute diverticulitis is a complication of diverticulosis that occurs when these outpouchings become infected. It is theorised that inflammation occurs when the entrance to the diverticulum is obstructed by faecal matter leading to bacterial overgrowth and partial necrosis of the diverticular wall. To date, consensus appears to be lacking on several aspects regarding the diagnostic approach and treatment of diverticulitis. This has led to a joint Dutch initiative, the Dutch Diverticular Disease Collaborative Study Group. This study group is a cooperation of the Academic Medical Center Amsterdam, Erasmus Medical Center Rotterdam, Kennemer Hospital Haarlem, Meander Medical Center Amersfoort, Saint Lucas Andreas Hospital Amsterdam aiming to deliver evidence in the form of both retrospective and prospective studies to end these persisting controversies.

AB - Diverticula are outpouchings that occur at week points in the colonic wall where small blood vessels enter the circular muscle layer. Diverticula are most frequently found in the distal part of the colon, with 90% of patients having the sigmoid colon involved. Most patients who have diverticulosis remain asymptomatic; however an estimated 15-20% will develop diverticulitis. Acute diverticulitis is a complication of diverticulosis that occurs when these outpouchings become infected. It is theorised that inflammation occurs when the entrance to the diverticulum is obstructed by faecal matter leading to bacterial overgrowth and partial necrosis of the diverticular wall. To date, consensus appears to be lacking on several aspects regarding the diagnostic approach and treatment of diverticulitis. This has led to a joint Dutch initiative, the Dutch Diverticular Disease Collaborative Study Group. This study group is a cooperation of the Academic Medical Center Amsterdam, Erasmus Medical Center Rotterdam, Kennemer Hospital Haarlem, Meander Medical Center Amersfoort, Saint Lucas Andreas Hospital Amsterdam aiming to deliver evidence in the form of both retrospective and prospective studies to end these persisting controversies.

KW - EWI-24636

KW - METIS-303015

KW - Diverticulitis

KW - IR-90457

M3 - PhD Thesis - Research external, graduation UT

SN - 978-94-6108-426-2

PB - Universiteit Twente

CY - Enschede

ER -

van de Wall BJM. Current status of treatment for diverticulitis. Enschede: Universiteit Twente, 2013. 164 p.