Deep Brain Stimulation - the challenges ahead

Tjitske Heida, J. Holsheimer, J.A.G. Geelen, Petrus H. Veltink

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    Abstract

    Parkinson’s disease (PD) is characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra, which results in reduced activity in the thalamus. Clinically effective deep brain stimulation (DBS) has been achieved with electrode contacts in the anterior- dorsal subthalamic nucleus (STN), globus pallidus internus (GPi) and ventral intermediate nucleus (Vim). Stimulation parameters (monopolar cathodic; 1-5 V amplitude; 60-200 μs pulse duration; 120-180 Hz frequency) have been established primarily by trial and error. Although DBS has substantially improved the suppression of symptoms in PD-patients: an average reduction of akinesia (42%), rigidity (49%), tremor (27%), the mechanism of DBS is still unclear and side- effects may occur (e.g. ocular deviation, hypophonia, speech disturbances). There is a lack of quantitative understanding of the influence of high-frequency stimulation on the neuronal elements surrounding the electrode and the neuronal systems involved.
    Original languageUndefined
    Title of host publicationProceedings of the 7th Meeting of the International Neuromodulation Society
    Place of PublicationPianoro, Italy
    PublisherInternational Neuromodulation Society
    Pages1-2
    Number of pages2
    ISBN (Print)978-88-7587-155-0
    Publication statusPublished - 2005
    Event7th International Neuromodulation Society Congress - Rome, Italy
    Duration: 10 Jun 200513 Jun 2005
    Conference number: 7

    Publication series

    Name
    PublisherMedimond

    Conference

    Conference7th International Neuromodulation Society Congress
    Abbreviated titleINS
    CountryItaly
    CityRome
    Period10/06/0513/06/05

    Keywords

    • METIS-226391
    • EWI-19931
    • IR-76577

    Cite this

    Heida, T., Holsheimer, J., Geelen, J. A. G., & Veltink, P. H. (2005). Deep Brain Stimulation - the challenges ahead. In Proceedings of the 7th Meeting of the International Neuromodulation Society (pp. 1-2). Pianoro, Italy: International Neuromodulation Society.
    Heida, Tjitske ; Holsheimer, J. ; Geelen, J.A.G. ; Veltink, Petrus H. / Deep Brain Stimulation - the challenges ahead. Proceedings of the 7th Meeting of the International Neuromodulation Society. Pianoro, Italy : International Neuromodulation Society, 2005. pp. 1-2
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    abstract = "Parkinson’s disease (PD) is characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra, which results in reduced activity in the thalamus. Clinically effective deep brain stimulation (DBS) has been achieved with electrode contacts in the anterior- dorsal subthalamic nucleus (STN), globus pallidus internus (GPi) and ventral intermediate nucleus (Vim). Stimulation parameters (monopolar cathodic; 1-5 V amplitude; 60-200 μs pulse duration; 120-180 Hz frequency) have been established primarily by trial and error. Although DBS has substantially improved the suppression of symptoms in PD-patients: an average reduction of akinesia (42{\%}), rigidity (49{\%}), tremor (27{\%}), the mechanism of DBS is still unclear and side- effects may occur (e.g. ocular deviation, hypophonia, speech disturbances). There is a lack of quantitative understanding of the influence of high-frequency stimulation on the neuronal elements surrounding the electrode and the neuronal systems involved.",
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    Heida, T, Holsheimer, J, Geelen, JAG & Veltink, PH 2005, Deep Brain Stimulation - the challenges ahead. in Proceedings of the 7th Meeting of the International Neuromodulation Society. International Neuromodulation Society, Pianoro, Italy, pp. 1-2, 7th International Neuromodulation Society Congress, Rome, Italy, 10/06/05.

    Deep Brain Stimulation - the challenges ahead. / Heida, Tjitske; Holsheimer, J.; Geelen, J.A.G.; Veltink, Petrus H.

    Proceedings of the 7th Meeting of the International Neuromodulation Society. Pianoro, Italy : International Neuromodulation Society, 2005. p. 1-2.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    N2 - Parkinson’s disease (PD) is characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra, which results in reduced activity in the thalamus. Clinically effective deep brain stimulation (DBS) has been achieved with electrode contacts in the anterior- dorsal subthalamic nucleus (STN), globus pallidus internus (GPi) and ventral intermediate nucleus (Vim). Stimulation parameters (monopolar cathodic; 1-5 V amplitude; 60-200 μs pulse duration; 120-180 Hz frequency) have been established primarily by trial and error. Although DBS has substantially improved the suppression of symptoms in PD-patients: an average reduction of akinesia (42%), rigidity (49%), tremor (27%), the mechanism of DBS is still unclear and side- effects may occur (e.g. ocular deviation, hypophonia, speech disturbances). There is a lack of quantitative understanding of the influence of high-frequency stimulation on the neuronal elements surrounding the electrode and the neuronal systems involved.

    AB - Parkinson’s disease (PD) is characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra, which results in reduced activity in the thalamus. Clinically effective deep brain stimulation (DBS) has been achieved with electrode contacts in the anterior- dorsal subthalamic nucleus (STN), globus pallidus internus (GPi) and ventral intermediate nucleus (Vim). Stimulation parameters (monopolar cathodic; 1-5 V amplitude; 60-200 μs pulse duration; 120-180 Hz frequency) have been established primarily by trial and error. Although DBS has substantially improved the suppression of symptoms in PD-patients: an average reduction of akinesia (42%), rigidity (49%), tremor (27%), the mechanism of DBS is still unclear and side- effects may occur (e.g. ocular deviation, hypophonia, speech disturbances). There is a lack of quantitative understanding of the influence of high-frequency stimulation on the neuronal elements surrounding the electrode and the neuronal systems involved.

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    Heida T, Holsheimer J, Geelen JAG, Veltink PH. Deep Brain Stimulation - the challenges ahead. In Proceedings of the 7th Meeting of the International Neuromodulation Society. Pianoro, Italy: International Neuromodulation Society. 2005. p. 1-2