Deep Brain Stimulation - the challenges ahead

Tjitske Heida, J. Holsheimer, J.A.G. Geelen, Petrus H. Veltink

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    Parkinson’s disease (PD) is characterized by progressive loss of dopamine neurons in the pars compacta of the substantia nigra, which results in reduced activity in the thalamus. Clinically effective deep brain stimulation (DBS) has been achieved with electrode contacts in the anterior- dorsal subthalamic nucleus (STN), globus pallidus internus (GPi) and ventral intermediate nucleus (Vim). Stimulation parameters (monopolar cathodic; 1-5 V amplitude; 60-200 μs pulse duration; 120-180 Hz frequency) have been established primarily by trial and error. Although DBS has substantially improved the suppression of symptoms in PD-patients: an average reduction of akinesia (42%), rigidity (49%), tremor (27%), the mechanism of DBS is still unclear and side- effects may occur (e.g. ocular deviation, hypophonia, speech disturbances). There is a lack of quantitative understanding of the influence of high-frequency stimulation on the neuronal elements surrounding the electrode and the neuronal systems involved.
    Original languageUndefined
    Title of host publicationProceedings of the 7th Meeting of the International Neuromodulation Society
    Place of PublicationPianoro, Italy
    PublisherInternational Neuromodulation Society
    Number of pages2
    ISBN (Print)978-88-7587-155-0
    Publication statusPublished - 2005
    Event7th International Neuromodulation Society Congress - Rome, Italy
    Duration: 10 Jun 200513 Jun 2005
    Conference number: 7

    Publication series



    Conference7th International Neuromodulation Society Congress
    Abbreviated titleINS


    • METIS-226391
    • EWI-19931
    • IR-76577

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