Deep learning for detection of focal epileptiform discharges from scalp EEG recordings

Marleen C. Tjepkema-Cloostermans* (Corresponding Author), Rafael C.V. de Carvalho, Michel J.A.M. van Putten

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
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Abstract

Objective: Visual assessment of the EEG still outperforms current computer algorithms in detecting epileptiform discharges. Deep learning is a promising novel approach, being able to learn from large datasets. Here, we show pilot results of detecting epileptiform discharges using deep neural networks. Methods: We selected 50 EEGs from focal epilepsy patients. All epileptiform discharges (n = 1815) were annotated by an experienced neurophysiologist and extracted as 2 s epochs. In addition, 50 normal EEGs were divided into 2 s epochs. All epochs were divided into a training (n = 41,381) and test (n = 8775) set. We implemented several combinations of convolutional and recurrent neural networks, providing the probability for the presence of epileptiform discharges. The network with the largest area under the ROC curve (AUC) in the test set was validated on seven independent EEGs with focal epileptiform discharges and twelve normal EEGs. Results: The final network had an AUC of 0.94 for the test set. Validation allowed detection of epileptiform discharges with 47.4% sensitivity and 98.0% specificity (FPR: 0.6/min). For the normal EEGs in the validation set, the specificity was 99.9% (FPR: 0.03/min). Conclusions: Deep neural networks can accurately detect epileptiform discharges from scalp EEG recordings. Significance: Deep learning may result in a fundamental shift in clinical EEG analysis.

Original languageEnglish
Pages (from-to)2191-2196
Number of pages6
JournalClinical neurophysiology
Volume129
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Convolutional neural networks
  • Deep learning
  • EEG
  • Epilepsy
  • Epileptiform discharges

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