Deficits in tapping accuracy and variability in tremor patients

Frauke Luft, Sarvi Sharifi, Winfred Mugge, Alfred C. Schouten, Lo J. Bour, Anne Fleur Van Rootselaar, Peter H. Veltink, Tijtske Heida

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Abstract

Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

Original languageEnglish
Article number54
JournalJournal of neuroengineering and rehabilitation
Volume16
Issue number1
DOIs
Publication statusPublished - 7 May 2019

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Tremor
Essential Tremor
Parkinson Disease
Cues
Basal Ganglia
Cerebellum
Walking
Hand
Control Groups
Brain

Keywords

  • Auditory cue
  • Essential tremor
  • Kinetic tremor
  • Parkinson's disease
  • Tapping accuracy
  • Tapping variability

Cite this

Luft, Frauke ; Sharifi, Sarvi ; Mugge, Winfred ; Schouten, Alfred C. ; Bour, Lo J. ; Van Rootselaar, Anne Fleur ; Veltink, Peter H. ; Heida, Tijtske. / Deficits in tapping accuracy and variability in tremor patients. In: Journal of neuroengineering and rehabilitation. 2019 ; Vol. 16, No. 1.
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abstract = "Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.",
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Deficits in tapping accuracy and variability in tremor patients. / Luft, Frauke; Sharifi, Sarvi; Mugge, Winfred; Schouten, Alfred C.; Bour, Lo J.; Van Rootselaar, Anne Fleur; Veltink, Peter H.; Heida, Tijtske.

In: Journal of neuroengineering and rehabilitation, Vol. 16, No. 1, 54, 07.05.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Deficits in tapping accuracy and variability in tremor patients

AU - Luft, Frauke

AU - Sharifi, Sarvi

AU - Mugge, Winfred

AU - Schouten, Alfred C.

AU - Bour, Lo J.

AU - Van Rootselaar, Anne Fleur

AU - Veltink, Peter H.

AU - Heida, Tijtske

PY - 2019/5/7

Y1 - 2019/5/7

N2 - Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

AB - Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

KW - Auditory cue

KW - Essential tremor

KW - Kinetic tremor

KW - Parkinson's disease

KW - Tapping accuracy

KW - Tapping variability

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DO - 10.1186/s12984-019-0528-6

M3 - Article

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JO - Journal of neuroengineering and rehabilitation

JF - Journal of neuroengineering and rehabilitation

SN - 1743-0003

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