Deficits in tapping accuracy and variability in tremor patients

Frauke Luft*, Sarvi Sharifi, Winfred Mugge, Alfred C. Schouten, Lo J. Bour, Anne Fleur Van Rootselaar, Peter H. Veltink, Tijtske Heida

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

    Original languageEnglish
    Article number54
    JournalJournal of neuroengineering and rehabilitation
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 7 May 2019

    Fingerprint

    Tremor
    Essential Tremor
    Parkinson Disease
    Cues
    Basal Ganglia
    Cerebellum
    Walking
    Hand
    Control Groups
    Brain

    Keywords

    • Auditory cue
    • Essential tremor
    • Kinetic tremor
    • Parkinson's disease
    • Tapping accuracy
    • Tapping variability

    Cite this

    Luft, Frauke ; Sharifi, Sarvi ; Mugge, Winfred ; Schouten, Alfred C. ; Bour, Lo J. ; Van Rootselaar, Anne Fleur ; Veltink, Peter H. ; Heida, Tijtske. / Deficits in tapping accuracy and variability in tremor patients. In: Journal of neuroengineering and rehabilitation. 2019 ; Vol. 16, No. 1.
    @article{3af67b845e8b4c50bf33d57119d8580a,
    title = "Deficits in tapping accuracy and variability in tremor patients",
    abstract = "Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.",
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    author = "Frauke Luft and Sarvi Sharifi and Winfred Mugge and Schouten, {Alfred C.} and Bour, {Lo J.} and {Van Rootselaar}, {Anne Fleur} and Veltink, {Peter H.} and Tijtske Heida",
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    doi = "10.1186/s12984-019-0528-6",
    language = "English",
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    Deficits in tapping accuracy and variability in tremor patients. / Luft, Frauke; Sharifi, Sarvi; Mugge, Winfred; Schouten, Alfred C.; Bour, Lo J.; Van Rootselaar, Anne Fleur; Veltink, Peter H.; Heida, Tijtske.

    In: Journal of neuroengineering and rehabilitation, Vol. 16, No. 1, 54, 07.05.2019.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Deficits in tapping accuracy and variability in tremor patients

    AU - Luft, Frauke

    AU - Sharifi, Sarvi

    AU - Mugge, Winfred

    AU - Schouten, Alfred C.

    AU - Bour, Lo J.

    AU - Van Rootselaar, Anne Fleur

    AU - Veltink, Peter H.

    AU - Heida, Tijtske

    PY - 2019/5/7

    Y1 - 2019/5/7

    N2 - Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

    AB - Background: The basal ganglia and cerebellum are brain structures involved in movement initiation, execution and termination. They are thought to be involved in the tremor generation and movement deficits in Parkinson's disease (PD) and essential tremor (ET). Especially in PD, maintaining cyclic movement, such as walking or tapping can be significantly disturbed. Providing external cues improves timing of these movements in PD but its effect on ET has not yet been studied in depth. The aim of this study is to evaluate the usefulness of a bimanual tapping task as a tool during clinical decision making. Method: Hand movements and tremor was recorded using accelerometers and EMG (m. extensor carpi ulnaris) from PD and ET patients and healthy controls during a bimanual tapping task as a way to distinguish PD from ET. All subjects performed the tapping task at two different frequencies, 2 Hz and 4 Hz, with and without the presence of auditory cues. Results: No significant intra-group differences were found in the patient groups. Acceleration data revealed significantly less accurate tapping and more variable tapping in PD than in ET and healthy controls. ET subjects tapped less accurate and with a greater variability than healthy controls during the 4 Hz tapping task. Most interestingly the tapping accuracy improved in PD patients when kinetic tremor was recorded with EMG during the task. Conclusion: Providing ET and PD patients with an external cue results in different tapping performances between patient groups and healthy controls. Furthermore, the findings suggest that kinetic tremor in PD enables patients to perform the task with a greater accuracy. So far this has not been shown in other studies.

    KW - Auditory cue

    KW - Essential tremor

    KW - Kinetic tremor

    KW - Parkinson's disease

    KW - Tapping accuracy

    KW - Tapping variability

    U2 - 10.1186/s12984-019-0528-6

    DO - 10.1186/s12984-019-0528-6

    M3 - Article

    AN - SCOPUS:85065414185

    VL - 16

    JO - Journal of neuroengineering and rehabilitation

    JF - Journal of neuroengineering and rehabilitation

    SN - 1743-0003

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    ER -