Delivery of gentamicin from resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis

G.A. ter Boo

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

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Abstract

This thesis describes the development of gentamicin loaded resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis and their in vitro and in vivo evaluation. Local delivery of antibiotics has several advantages in the case of trauma to the bone and surrounding tissues. It can deliver high amounts of antibiotics directly to the target site, without inducing toxicity in non-target organs. Furthermore, sufficient antibiotic levels can be reached by local application at sites where the vasculature is disturbed.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Grijpma, D.W., Supervisor
  • Eglin, D., Advisor
Award date2 Nov 2016
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-4231-9
DOIs
Publication statusPublished - 2 Nov 2016

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Osteomyelitis
Gentamicins
Anti-Bacterial Agents
Bone and Bones
Wounds and Injuries

Keywords

  • METIS-318363
  • IR-101846

Cite this

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Delivery of gentamicin from resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis. / ter Boo, G.A.

Enschede : Universiteit Twente, 2016. 188 p.

Research output: ThesisPhD Thesis - Research external, graduation UTAcademic

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AB - This thesis describes the development of gentamicin loaded resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis and their in vitro and in vivo evaluation. Local delivery of antibiotics has several advantages in the case of trauma to the bone and surrounding tissues. It can deliver high amounts of antibiotics directly to the target site, without inducing toxicity in non-target organs. Furthermore, sufficient antibiotic levels can be reached by local application at sites where the vasculature is disturbed.

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