Delivery of Timolol through Artificial Membranes and Pig Stratum Corneum

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The in vitro passive and iontophoretic (applied current density: 0.5 mA/cm2) timolol (TM) permeability from a liquid solution through pig stratum corneum (SC) is found to be 0.9 ± 0.5 × 10-6 and 3.9 ± 0.9 × 10-6 cm/s, respectively. The in vitro iontophoretic TM delivery through the combination of artificial porous membranes with pig SC is investigated as well. When the meso-porous PES-30 membrane is applied, the SC mainly controls the TM delivery. When the microporous NF-PES-10 membrane is applied, both the membrane and the SC contribute to controlling the delivery of TM. When the microporous LFC 1 membrane is applied, the TM delivery is membrane controlled. In all cases, however, the efficiency of the TM delivery is low and would need to be improved for the development of a commercially viable product.
Original languageUndefined
Pages (from-to)1037-1039
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume92
Issue number5
DOIs
Publication statusPublished - 2003

Keywords

  • iontophoresis
  • METIS-214430
  • IR-71901
  • artificial membranes
  • Pig stratum corneum
  • timolol

Cite this

@article{9daf247163cb4a3486b907f0e3883e83,
title = "Delivery of Timolol through Artificial Membranes and Pig Stratum Corneum",
abstract = "The in vitro passive and iontophoretic (applied current density: 0.5 mA/cm2) timolol (TM) permeability from a liquid solution through pig stratum corneum (SC) is found to be 0.9 ± 0.5 × 10-6 and 3.9 ± 0.9 × 10-6 cm/s, respectively. The in vitro iontophoretic TM delivery through the combination of artificial porous membranes with pig SC is investigated as well. When the meso-porous PES-30 membrane is applied, the SC mainly controls the TM delivery. When the microporous NF-PES-10 membrane is applied, both the membrane and the SC contribute to controlling the delivery of TM. When the microporous LFC 1 membrane is applied, the TM delivery is membrane controlled. In all cases, however, the efficiency of the TM delivery is low and would need to be improved for the development of a commercially viable product.",
keywords = "iontophoresis, METIS-214430, IR-71901, artificial membranes, Pig stratum corneum, timolol",
author = "Dimitrios Stamatialis and Rolevink, {Hendrikus H.M.} and G.H. Koops",
year = "2003",
doi = "10.1002/jps.10387",
language = "Undefined",
volume = "92",
pages = "1037--1039",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Wiley",
number = "5",

}

Delivery of Timolol through Artificial Membranes and Pig Stratum Corneum. / Stamatialis, Dimitrios; Rolevink, Hendrikus H.M.; Koops, G.H.

In: Journal of Pharmaceutical Sciences, Vol. 92, No. 5, 2003, p. 1037-1039.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Delivery of Timolol through Artificial Membranes and Pig Stratum Corneum

AU - Stamatialis, Dimitrios

AU - Rolevink, Hendrikus H.M.

AU - Koops, G.H.

PY - 2003

Y1 - 2003

N2 - The in vitro passive and iontophoretic (applied current density: 0.5 mA/cm2) timolol (TM) permeability from a liquid solution through pig stratum corneum (SC) is found to be 0.9 ± 0.5 × 10-6 and 3.9 ± 0.9 × 10-6 cm/s, respectively. The in vitro iontophoretic TM delivery through the combination of artificial porous membranes with pig SC is investigated as well. When the meso-porous PES-30 membrane is applied, the SC mainly controls the TM delivery. When the microporous NF-PES-10 membrane is applied, both the membrane and the SC contribute to controlling the delivery of TM. When the microporous LFC 1 membrane is applied, the TM delivery is membrane controlled. In all cases, however, the efficiency of the TM delivery is low and would need to be improved for the development of a commercially viable product.

AB - The in vitro passive and iontophoretic (applied current density: 0.5 mA/cm2) timolol (TM) permeability from a liquid solution through pig stratum corneum (SC) is found to be 0.9 ± 0.5 × 10-6 and 3.9 ± 0.9 × 10-6 cm/s, respectively. The in vitro iontophoretic TM delivery through the combination of artificial porous membranes with pig SC is investigated as well. When the meso-porous PES-30 membrane is applied, the SC mainly controls the TM delivery. When the microporous NF-PES-10 membrane is applied, both the membrane and the SC contribute to controlling the delivery of TM. When the microporous LFC 1 membrane is applied, the TM delivery is membrane controlled. In all cases, however, the efficiency of the TM delivery is low and would need to be improved for the development of a commercially viable product.

KW - iontophoresis

KW - METIS-214430

KW - IR-71901

KW - artificial membranes

KW - Pig stratum corneum

KW - timolol

U2 - 10.1002/jps.10387

DO - 10.1002/jps.10387

M3 - Article

VL - 92

SP - 1037

EP - 1039

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 5

ER -