Dependence of nociceptive detection thresholds on physiological parameters and capsaicin-induced neuroplasticity: a computational study

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Abstract

Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. Here, we aim to understand how these alterations affect Aδ-fiber-mediated nociceptive detection of electrocutaneous stimuli. First, with a neurophysiology-based model, we study the effects of single-model parameters on detection thresholds. Second, we derive an expression of model parameters determining the functional relationship between detection thresholds and the interpulse interval for double-pulse stimuli. Third, in a case study with topical capsaicin treatment, we translate neuroplasticity into plausible changes of model parameters. Model simulations qualitatively agree with changes in experimental detection thresholds. The simulations with individual forms of neuroplasticity confirm that nerve degeneration is the dominant mechanism for capsaicin-induced increases in detection thresholds. In addition, our study suggests that capsaicin-induced central plasticity may last at least 1 month.
Original languageUndefined
Pages (from-to)12
Number of pages12
JournalFrontiers in computational neuroscience
Volume10
Issue number49
DOIs
Publication statusPublished - 25 May 2016

Keywords

  • EWI-27047
  • detection threshold
  • neuroplasticity
  • IR-100480
  • Capsaicin
  • Computational modeling
  • METIS-317213
  • nociceptive detection

Cite this

@article{465f1245635040a2ac370536a888c2f1,
title = "Dependence of nociceptive detection thresholds on physiological parameters and capsaicin-induced neuroplasticity: a computational study",
abstract = "Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. Here, we aim to understand how these alterations affect Aδ-fiber-mediated nociceptive detection of electrocutaneous stimuli. First, with a neurophysiology-based model, we study the effects of single-model parameters on detection thresholds. Second, we derive an expression of model parameters determining the functional relationship between detection thresholds and the interpulse interval for double-pulse stimuli. Third, in a case study with topical capsaicin treatment, we translate neuroplasticity into plausible changes of model parameters. Model simulations qualitatively agree with changes in experimental detection thresholds. The simulations with individual forms of neuroplasticity confirm that nerve degeneration is the dominant mechanism for capsaicin-induced increases in detection thresholds. In addition, our study suggests that capsaicin-induced central plasticity may last at least 1 month.",
keywords = "EWI-27047, detection threshold, neuroplasticity, IR-100480, Capsaicin, Computational modeling, METIS-317213, nociceptive detection",
author = "H. Yang and Meijer, {Hil Ga{\'e}tan Ellart} and Robert Doll and Buitenweg, {Jan R.} and {van Gils}, {Stephanus A.}",
note = "eemcs-eprint-27047",
year = "2016",
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doi = "10.3389/fncom.2016.00049",
language = "Undefined",
volume = "10",
pages = "12",
journal = "Frontiers in computational neuroscience",
issn = "1662-5188",
publisher = "Frontiers Media S.A.",
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TY - JOUR

T1 - Dependence of nociceptive detection thresholds on physiological parameters and capsaicin-induced neuroplasticity: a computational study

AU - Yang, H.

AU - Meijer, Hil Gaétan Ellart

AU - Doll, Robert

AU - Buitenweg, Jan R.

AU - van Gils, Stephanus A.

N1 - eemcs-eprint-27047

PY - 2016/5/25

Y1 - 2016/5/25

N2 - Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. Here, we aim to understand how these alterations affect Aδ-fiber-mediated nociceptive detection of electrocutaneous stimuli. First, with a neurophysiology-based model, we study the effects of single-model parameters on detection thresholds. Second, we derive an expression of model parameters determining the functional relationship between detection thresholds and the interpulse interval for double-pulse stimuli. Third, in a case study with topical capsaicin treatment, we translate neuroplasticity into plausible changes of model parameters. Model simulations qualitatively agree with changes in experimental detection thresholds. The simulations with individual forms of neuroplasticity confirm that nerve degeneration is the dominant mechanism for capsaicin-induced increases in detection thresholds. In addition, our study suggests that capsaicin-induced central plasticity may last at least 1 month.

AB - Physiological properties of peripheral and central nociceptive subsystems can be altered over time due to medical interventions. The effective change for the whole nociceptive system can be reflected in changes of psychophysical characteristics, e.g., detection thresholds. However, it is challenging to separate contributions of distinct altered mechanisms with measurements of thresholds only. Here, we aim to understand how these alterations affect Aδ-fiber-mediated nociceptive detection of electrocutaneous stimuli. First, with a neurophysiology-based model, we study the effects of single-model parameters on detection thresholds. Second, we derive an expression of model parameters determining the functional relationship between detection thresholds and the interpulse interval for double-pulse stimuli. Third, in a case study with topical capsaicin treatment, we translate neuroplasticity into plausible changes of model parameters. Model simulations qualitatively agree with changes in experimental detection thresholds. The simulations with individual forms of neuroplasticity confirm that nerve degeneration is the dominant mechanism for capsaicin-induced increases in detection thresholds. In addition, our study suggests that capsaicin-induced central plasticity may last at least 1 month.

KW - EWI-27047

KW - detection threshold

KW - neuroplasticity

KW - IR-100480

KW - Capsaicin

KW - Computational modeling

KW - METIS-317213

KW - nociceptive detection

U2 - 10.3389/fncom.2016.00049

DO - 10.3389/fncom.2016.00049

M3 - Article

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JO - Frontiers in computational neuroscience

JF - Frontiers in computational neuroscience

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ER -