Depth limitations for in vivo magnetic nanoparticle detection with a compact handheld device

Martijn Visscher, Sebastiaan Waanders, Joost Pouw, Bennie ten Haken*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
245 Downloads (Pure)

Abstract

The increasing interest for local detection of magnetic nanoparticles (MNPs) during clinical interventions requires the development of suitable probes that unambiguously detect the MNPs at a depth of several centimeters in the body. The present study quantitatively evaluates the limitations of a conventional magnetometry method using a sinusoidal alternating field. This method is limited by the variability of the magnetic susceptibility of the surrounding diamagnetic tissue. Two different sensors are evaluated in a theoretical model of MNP detection in a tissue volume. For a coil that completely encloses the sample volume, the MNPs can be detected if the total mass contributing to the signal is larger than 4.1×10-7 times the tissue mass. For a handheld surface coil, intended to search for the MNPs in a larger tissue volume, an amount of 1 μg of iron oxide cannot be detected by sensors with a diameter larger than 15 mm. To detect a spot with MNPs at 5 cm depth in tissue, it should contain at least 325 μg iron oxide. Therefore, for high-sensitive clinical MNP detection in surgical interventions, techniques with increased specificity for the nonlinear magnetic properties of MNPs are indispensable.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalJournal of magnetism and magnetic materials
Volume380
DOIs
Publication statusPublished - 15 Apr 2015

Keywords

  • Biomedical sensing
  • Diamagnetism of tissue
  • In vivo detection
  • Intraoperative sentinel lymph node detection
  • Magnetic nanoparticle
  • Nonlinear susceptibility
  • 2023 OA procedure

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