Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone

A.A. Deschamps, M.B. Claase, Warnerie J. Sleijster, Joost Dick de Bruijn, Dirk W. Grijpma, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

106 Citations (Scopus)

Abstract

In this study, PEOT/PBT segmented copolymers of different compositions have been evaluated as possible scaffold materials for the tissue engineering of bone. By changing the composition of PEOT/PBT copolymers, very different mechanical and swelling behaviors are observed. Tensile strengths vary from 8 to 23 MPa and elongations at break from 500 to 1300%. Water-uptake ranges from 4 up to as high as 210%. The in vitro degradation of PEOT/PBT copolymers occurs both by hydrolysis and oxidation. In both cases degradation is more rapid for copolymers with high PEO content. PEOT/PBT scaffolds with varying porosities and pore sizes have been prepared by molding and freeze-drying techniques in combination with particulate-leaching. The most hydrophilic PEOT/PBT copolymers did not sustain goat bone marrow cell adhesion and growth. However, surface modification by gas plasma treatment showed a very much improved polymer–cell interaction for all PEOT/PBT copolymer compositions. Their mechanical properties, degradability and ability to sustain bone marrow cell growth make PEOT/PBT copolymers excellent materials for bone tissue engineering.
Original languageUndefined
Pages (from-to)175-186
JournalJournal of controlled release
Volume78
Issue number1-3
DOIs
Publication statusPublished - 2002

Keywords

  • IR-74695
  • Degradation
  • METIS-211011
  • Bone
  • Segmented poly(ether ester)s
  • Tissue Engineering

Cite this

Deschamps, A.A. ; Claase, M.B. ; Sleijster, Warnerie J. ; de Bruijn, Joost Dick ; Grijpma, Dirk W. ; Feijen, Jan. / Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone. In: Journal of controlled release. 2002 ; Vol. 78, No. 1-3. pp. 175-186.
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abstract = "In this study, PEOT/PBT segmented copolymers of different compositions have been evaluated as possible scaffold materials for the tissue engineering of bone. By changing the composition of PEOT/PBT copolymers, very different mechanical and swelling behaviors are observed. Tensile strengths vary from 8 to 23 MPa and elongations at break from 500 to 1300{\%}. Water-uptake ranges from 4 up to as high as 210{\%}. The in vitro degradation of PEOT/PBT copolymers occurs both by hydrolysis and oxidation. In both cases degradation is more rapid for copolymers with high PEO content. PEOT/PBT scaffolds with varying porosities and pore sizes have been prepared by molding and freeze-drying techniques in combination with particulate-leaching. The most hydrophilic PEOT/PBT copolymers did not sustain goat bone marrow cell adhesion and growth. However, surface modification by gas plasma treatment showed a very much improved polymer–cell interaction for all PEOT/PBT copolymer compositions. Their mechanical properties, degradability and ability to sustain bone marrow cell growth make PEOT/PBT copolymers excellent materials for bone tissue engineering.",
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author = "A.A. Deschamps and M.B. Claase and Sleijster, {Warnerie J.} and {de Bruijn}, {Joost Dick} and Grijpma, {Dirk W.} and Jan Feijen",
year = "2002",
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volume = "78",
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Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone. / Deschamps, A.A.; Claase, M.B.; Sleijster, Warnerie J.; de Bruijn, Joost Dick; Grijpma, Dirk W.; Feijen, Jan.

In: Journal of controlled release, Vol. 78, No. 1-3, 2002, p. 175-186.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone

AU - Deschamps, A.A.

AU - Claase, M.B.

AU - Sleijster, Warnerie J.

AU - de Bruijn, Joost Dick

AU - Grijpma, Dirk W.

AU - Feijen, Jan

PY - 2002

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AB - In this study, PEOT/PBT segmented copolymers of different compositions have been evaluated as possible scaffold materials for the tissue engineering of bone. By changing the composition of PEOT/PBT copolymers, very different mechanical and swelling behaviors are observed. Tensile strengths vary from 8 to 23 MPa and elongations at break from 500 to 1300%. Water-uptake ranges from 4 up to as high as 210%. The in vitro degradation of PEOT/PBT copolymers occurs both by hydrolysis and oxidation. In both cases degradation is more rapid for copolymers with high PEO content. PEOT/PBT scaffolds with varying porosities and pore sizes have been prepared by molding and freeze-drying techniques in combination with particulate-leaching. The most hydrophilic PEOT/PBT copolymers did not sustain goat bone marrow cell adhesion and growth. However, surface modification by gas plasma treatment showed a very much improved polymer–cell interaction for all PEOT/PBT copolymer compositions. Their mechanical properties, degradability and ability to sustain bone marrow cell growth make PEOT/PBT copolymers excellent materials for bone tissue engineering.

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