Design strategy and process optimization for reactors with continuous transport of an immobilized enzyme

Hendrik J. Vos, K.Ch.A.M. Luyben, K.R. Westerterp

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Abstract

In order to operate a process which uses immobilized enzymes at constant conversion and constant capacity, the refreshment of the enzyme must be continuous. In this paper, two reactor types with continuous refreshment of the biocatalyst are discussed: the stirred tank and the multistage fluidized bed. A method is presented for dimensioning a reactor in such a way that the costs for the conversion of substrate to product are minimized. These costs are calculated as the sum of the biocatalyst consumption and overall reactor costs. In contrast with the stirred-tank reactor, the multistage fluidized bed can be operated at a non-uniform temperature. For the glucose isomerase process, an optimal temperature gradient results in a small reduction in the biocatalyst consumption (±5%). It is concluded that, in general, a temperature gradient will only favour the economy of processes with relatively expensive biocatalysts. Compared with conventional reactor types, such as the continuous stirred-tank reactor and the fixed-bed reactor, the multistage fluidized-bed reactor can improve the economy of an enzyme-catalysed reaction significantly.
Original languageUndefined
Pages (from-to)B1-B11
JournalThe Chemical Engineering Journal and the Biochemical Engineering Journal
Volume53
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • IR-57408

Cite this

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title = "Design strategy and process optimization for reactors with continuous transport of an immobilized enzyme",
abstract = "In order to operate a process which uses immobilized enzymes at constant conversion and constant capacity, the refreshment of the enzyme must be continuous. In this paper, two reactor types with continuous refreshment of the biocatalyst are discussed: the stirred tank and the multistage fluidized bed. A method is presented for dimensioning a reactor in such a way that the costs for the conversion of substrate to product are minimized. These costs are calculated as the sum of the biocatalyst consumption and overall reactor costs. In contrast with the stirred-tank reactor, the multistage fluidized bed can be operated at a non-uniform temperature. For the glucose isomerase process, an optimal temperature gradient results in a small reduction in the biocatalyst consumption (±5{\%}). It is concluded that, in general, a temperature gradient will only favour the economy of processes with relatively expensive biocatalysts. Compared with conventional reactor types, such as the continuous stirred-tank reactor and the fixed-bed reactor, the multistage fluidized-bed reactor can improve the economy of an enzyme-catalysed reaction significantly.",
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author = "Vos, {Hendrik J.} and K.Ch.A.M. Luyben and K.R. Westerterp",
year = "1993",
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language = "Undefined",
volume = "53",
pages = "B1--B11",
journal = "The Chemical Engineering Journal and the Biochemical Engineering Journal",
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Design strategy and process optimization for reactors with continuous transport of an immobilized enzyme. / Vos, Hendrik J.; Luyben, K.Ch.A.M.; Westerterp, K.R.

In: The Chemical Engineering Journal and the Biochemical Engineering Journal, Vol. 53, No. 1, 1993, p. B1-B11.

Research output: Contribution to journalArticleAcademic

TY - JOUR

T1 - Design strategy and process optimization for reactors with continuous transport of an immobilized enzyme

AU - Vos, Hendrik J.

AU - Luyben, K.Ch.A.M.

AU - Westerterp, K.R.

PY - 1993

Y1 - 1993

N2 - In order to operate a process which uses immobilized enzymes at constant conversion and constant capacity, the refreshment of the enzyme must be continuous. In this paper, two reactor types with continuous refreshment of the biocatalyst are discussed: the stirred tank and the multistage fluidized bed. A method is presented for dimensioning a reactor in such a way that the costs for the conversion of substrate to product are minimized. These costs are calculated as the sum of the biocatalyst consumption and overall reactor costs. In contrast with the stirred-tank reactor, the multistage fluidized bed can be operated at a non-uniform temperature. For the glucose isomerase process, an optimal temperature gradient results in a small reduction in the biocatalyst consumption (±5%). It is concluded that, in general, a temperature gradient will only favour the economy of processes with relatively expensive biocatalysts. Compared with conventional reactor types, such as the continuous stirred-tank reactor and the fixed-bed reactor, the multistage fluidized-bed reactor can improve the economy of an enzyme-catalysed reaction significantly.

AB - In order to operate a process which uses immobilized enzymes at constant conversion and constant capacity, the refreshment of the enzyme must be continuous. In this paper, two reactor types with continuous refreshment of the biocatalyst are discussed: the stirred tank and the multistage fluidized bed. A method is presented for dimensioning a reactor in such a way that the costs for the conversion of substrate to product are minimized. These costs are calculated as the sum of the biocatalyst consumption and overall reactor costs. In contrast with the stirred-tank reactor, the multistage fluidized bed can be operated at a non-uniform temperature. For the glucose isomerase process, an optimal temperature gradient results in a small reduction in the biocatalyst consumption (±5%). It is concluded that, in general, a temperature gradient will only favour the economy of processes with relatively expensive biocatalysts. Compared with conventional reactor types, such as the continuous stirred-tank reactor and the fixed-bed reactor, the multistage fluidized-bed reactor can improve the economy of an enzyme-catalysed reaction significantly.

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U2 - 10.1016/0923-0467(93)80011-K

DO - 10.1016/0923-0467(93)80011-K

M3 - Article

VL - 53

SP - B1-B11

JO - The Chemical Engineering Journal and the Biochemical Engineering Journal

JF - The Chemical Engineering Journal and the Biochemical Engineering Journal

SN - 0923-0467

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