Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins

Tetsu M. Seck, F.P.W. Melchels, Jan Feijen, Dirk W. Grijpma

Research output: Contribution to journalArticleAcademicpeer-review

116 Citations (Scopus)

Abstract

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(d,l-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.
Original languageEnglish
Pages (from-to)34-41
JournalJournal of controlled release
Volume148
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Designed porous structures
  • Stereolithography
  • Tissue Engineering
  • Biodegradable hydrogels
  • IR-80283
  • Macromer photo-polymerisation
  • METIS-272859

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