Detection of Circulating Tumor Cells

Sanne Mutter-de Wit, Guus van Dalum, Leonardus Wendelinus Mathias Marie Terstappen

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The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements
Original languageEnglish
Article number819362
Pages (from-to)-
Number of pages11
Issue number819362
Publication statusPublished - 2014


  • METIS-304908
  • IR-94900


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