Detection of Pathogens with Impedance Analysis in a Lab on a Chip

E.J. van der Wouden, M. Super, D.E. Ingber, Albert van den Berg

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    Abstract

    In this work, we demonstrate an impedance approach to detect pathogens bound to magnetic beads. The approach was demonstrated with C-Albicans. We show that when an appropriate frequency is applied to two electrodes present in a microfluidic channel the impedance change in the detection volume can be used to distinguish between unbound beads and beads bound to pathogens. Furthermore, we present a model to relate measured impedance changes to an effective particle diameter.
    Original languageUndefined
    Pages (from-to)1465-1468
    Number of pages4
    JournalProcedia engineering
    Volume25
    DOIs
    Publication statusPublished - 4 Sep 2011
    Event21st European Conference on Solid-State Transducers, Eurosensors XXV 2011 - Athens, Greece
    Duration: 4 Sep 20117 Sep 2011
    Conference number: 21

    Keywords

    • magnetic beads
    • sepsis
    • EWI-20930
    • IR-78790
    • Lab on a chip
    • METIS-281615
    • Impedance analyses

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