Detection of Pathogens with Impedance Analysis in a Lab on a Chip

E.J. van der Wouden; M. Super; D.E. Ingber; A. van den Berg

doi:10.1016/j.proeng.2011.12.362

Detection of Pathogens with Impedance Analysis in a Lab on a Chip

E.J. van der Wouden^*
, M. Super
, D.E. Ingber
, A. van den Berg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

199 Downloads (Pure)

Abstract

In this work, we demonstrate an impedance approach to detect pathogens bound to magnetic beads. The approach was demonstrated with C-Albicans. We show that when an appropriate frequency is applied to two electrodes present in a microfluidic channel the impedance change in the detection volume can be used to distinguish between unbound beads and beads bound to pathogens. Furthermore, we present a model to relate measured impedance changes to an effective particle diameter.

Original language	English
Pages (from-to)	1465-1468
Number of pages	4
Journal	Procedia engineering
Volume	25
DOIs	https://doi.org/10.1016/j.proeng.2011.12.362
Publication status	Published - 4 Sept 2011
Event	21st European Conference on Solid-State Transducers, Eurosensors XXV 2011 - Athens, Greece Duration: 4 Sept 2011 → 7 Sept 2011 Conference number: 21

Keywords

Magnetic beads
Sepsis
Lab on a chip
Impedance analyses

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10.1016/j.proeng.2011.12.362Licence: CC BY-NC-ND

ArticleFinal published version, 200 KBLicence: CC BY-NC-ND

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title = "Detection of Pathogens with Impedance Analysis in a Lab on a Chip",

abstract = "In this work, we demonstrate an impedance approach to detect pathogens bound to magnetic beads. The approach was demonstrated with C-Albicans. We show that when an appropriate frequency is applied to two electrodes present in a microfluidic channel the impedance change in the detection volume can be used to distinguish between unbound beads and beads bound to pathogens. Furthermore, we present a model to relate measured impedance changes to an effective particle diameter.",

keywords = "Magnetic beads, Sepsis, Lab on a chip, Impedance analyses",

author = "\{van der Wouden\}, E.J. and M. Super and D.E. Ingber and \{van den Berg\}, A.",

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journal = "Procedia engineering",

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note = "21st European Conference on Solid-State Transducers, Eurosensors XXV 2011, Eurosensors ; Conference date: 04-09-2011 Through 07-09-2011",

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TY - JOUR

T1 - Detection of Pathogens with Impedance Analysis in a Lab on a Chip

AU - van der Wouden, E.J.

AU - Super, M.

AU - Ingber, D.E.

AU - van den Berg, A.

N1 - Conference code: 21

PY - 2011/9/4

Y1 - 2011/9/4

N2 - In this work, we demonstrate an impedance approach to detect pathogens bound to magnetic beads. The approach was demonstrated with C-Albicans. We show that when an appropriate frequency is applied to two electrodes present in a microfluidic channel the impedance change in the detection volume can be used to distinguish between unbound beads and beads bound to pathogens. Furthermore, we present a model to relate measured impedance changes to an effective particle diameter.

AB - In this work, we demonstrate an impedance approach to detect pathogens bound to magnetic beads. The approach was demonstrated with C-Albicans. We show that when an appropriate frequency is applied to two electrodes present in a microfluidic channel the impedance change in the detection volume can be used to distinguish between unbound beads and beads bound to pathogens. Furthermore, we present a model to relate measured impedance changes to an effective particle diameter.

KW - Magnetic beads

KW - Sepsis

KW - Lab on a chip

KW - Impedance analyses

U2 - 10.1016/j.proeng.2011.12.362

DO - 10.1016/j.proeng.2011.12.362

M3 - Article

SN - 1877-7058

VL - 25

SP - 1465

EP - 1468

JO - Procedia engineering

JF - Procedia engineering

T2 - 21st European Conference on Solid-State Transducers, Eurosensors XXV 2011

Y2 - 4 September 2011 through 7 September 2011

ER -

Detection of Pathogens with Impedance Analysis in a Lab on a Chip

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Keywords

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