TY - JOUR
T1 - Determinants of orthostatic cerebral oxygenation assessed using near-infrared spectroscopy
AU - Mol, Arjen
AU - Claassen, Jurgen A.H.R.
AU - Maier, Andrea B.
AU - van Wezel, Richard J.A.
AU - Meskers, Carel G.M.
N1 - Funding Information:
This study was supported by a grant from the Applied and Engineering Science domain (TTW) of the Netherlands Organization of Scientific Research (NWO): NeuroCIMT- Barocontrol (grant no 14901 ).
Funding Information:
We kindly acknowledge Lois Slangen, Marlous Verhulst and Jeffrey Woltering for assisting in the data collection. All participants signed informed consent and the study was performed in accordance with the Declaration of Helsinki and approved by the Ethics committee of the Faculty of Science of the Radboud University, Nijmegen (study approval reference number: REC18021). AM, JAHRC, ABM, RJAvW and CM conceived of the presented idea and designed the study. AM performed the data collection. AM performed the analysis and took the lead in writing the manuscript. All authors discussed the results and contributed to the final manuscript. All authors approved the final version of the manuscript and agree to be accountable for the study. All persons designated as authors qualify for authorship, and all those who qualify for authorship are listed. This study was supported by a grant from the Applied and Engineering Science domain (TTW) of the Netherlands Organization of Scientific Research (NWO): NeuroCIMT- Barocontrol (grant no 14901).
Publisher Copyright:
© 2022 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - Background: To understand the relationship between blood pressure changes during standing up and clinical outcome, cerebral oxygenation needs to be measured, which may be performed using near-infrared spectroscopy (NIRS). However, the role of potential determinants of NIRS-derived orthostatic cerebral oxygenation, i.e., age, sex, type of postural change (i.e., standing up from sitting versus supine position), blood pressure (BP) and baroreflex sensitivity (BRS) is still unknown and needed to better interpret findings from studies using orthostatic NIRS measurements. Methods: 34 younger (median age 25 years, inter quartile range (IQR) 22–45) and 31 older adults (median age 77 years, IQR 72–81) underwent BP, BRS and NIRS measurements during standing up from sitting and supine position. Linear regression models were used to assess the potential determinant role of age, sex, type of postural change, BP and BRS in orthostatic cerebral oxygenation drop and recovery. Orthostatic cerebral oxygenation test-retest reliability was assessed using intra class correlations. Results: Younger age, male sex and standing up from supine compared to sitting position were positively associated with cerebral oxygenation drop; older age and standing up from sitting compared to supine position were associated with higher cerebral oxygenation recovery. Test-retest reliability was highest (ICC > 0.83) during standing up from supine position. Conclusion: Based on the findings of this study, age, sex and type of postural change are significant determinants of NIRS-derived orthostatic cerebral oxygenation and should be taken into account in the interpretation of NIRS measurements. In the design of new studies, standing up from supine position is preferable (higher reliability) over standing up from sitting position.
AB - Background: To understand the relationship between blood pressure changes during standing up and clinical outcome, cerebral oxygenation needs to be measured, which may be performed using near-infrared spectroscopy (NIRS). However, the role of potential determinants of NIRS-derived orthostatic cerebral oxygenation, i.e., age, sex, type of postural change (i.e., standing up from sitting versus supine position), blood pressure (BP) and baroreflex sensitivity (BRS) is still unknown and needed to better interpret findings from studies using orthostatic NIRS measurements. Methods: 34 younger (median age 25 years, inter quartile range (IQR) 22–45) and 31 older adults (median age 77 years, IQR 72–81) underwent BP, BRS and NIRS measurements during standing up from sitting and supine position. Linear regression models were used to assess the potential determinant role of age, sex, type of postural change, BP and BRS in orthostatic cerebral oxygenation drop and recovery. Orthostatic cerebral oxygenation test-retest reliability was assessed using intra class correlations. Results: Younger age, male sex and standing up from supine compared to sitting position were positively associated with cerebral oxygenation drop; older age and standing up from sitting compared to supine position were associated with higher cerebral oxygenation recovery. Test-retest reliability was highest (ICC > 0.83) during standing up from supine position. Conclusion: Based on the findings of this study, age, sex and type of postural change are significant determinants of NIRS-derived orthostatic cerebral oxygenation and should be taken into account in the interpretation of NIRS measurements. In the design of new studies, standing up from supine position is preferable (higher reliability) over standing up from sitting position.
KW - Aging
KW - Baroreflex
KW - Blood pressure
KW - Cerebrovascular circulation
KW - NIRS
KW - Orthostatic hypotension
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85123944336&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2022.102942
DO - 10.1016/j.autneu.2022.102942
M3 - Review article
C2 - 35124323
AN - SCOPUS:85123944336
SN - 1566-0702
VL - 238
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
M1 - 102942
ER -