Determinants of 18F-NaF uptake in femoral arteries in patients with type 2 diabetes mellitus

Richard A.P. Takx*, Ruth van Asperen, Jonas W. Bartstra, Sabine R. Zwakenberg, Jelmer M. Wolterink, Csilla Celeng, Pim A. de Jong, Joline W. Beulens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
13 Downloads (Pure)

Abstract

Background: The goal of this study was to investigate the potential determinants of 18F-NaF uptake in femoral arteries as a marker of arterial calcification in patients with type 2 diabetes and a history of arterial disease.

Methods and Results: The study consisted of participants of a randomized controlled trial to investigate the effect of vitamin K2 (NCT02839044). In this prespecified analysis, subjects with type 2 diabetes and known arterial disease underwent full body 18F-NaF PET/CT. Target-to-background ratio (TBR) was calculated by dividing the mean SUVmax from both superficial femoral arteries by the SUVmean in the superior vena cava (SVC) and calcium mass was measured on CT. The association between 18F-NaF TBR and cardiovascular risk factors was investigated using uni- and multivariate linear regression corrected for age and sex. In total, 68 patients (mean age: 69 ± 8 years; male: 52) underwent 18F-NaF PET/CT. Higher CT calcium mass, total cholesterol, and HbA1c were associated with higher 18F-NaF TBR after adjusting.

Conclusion: This study shows that several modifiable cardiovascular risk factors (total cholesterol, triglycerides, HbA1c) are associated with femoral 18F-NaF tracer uptake in patients with type 2 diabetes.

Original languageEnglish
Number of pages6
JournalJournal of nuclear cardiology
DOIs
Publication statusE-pub ahead of print/First online - 17 Mar 2020
Externally publishedYes

Keywords

  • Atherosclerosis
  • CT
  • Diabetes
  • PAD
  • PET

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