Determination of the helical sense in alanine based polyisocyanides

Jeroen J.L.M. Cornelissen, Nico A.J.M. Sommerdijk*, Roeland J.M. Nolte

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

Abstract

The assignment of the helix sense in poly-(isocyano amino acids) and poly(isocyano peptides) using circular dichroism (CD) spectroscopy is hampered due to overlap of signals arising from the polymer backbone and the side chains. By comparing the CD spectrum of an L-alanine based polyisocyanide containing a spectator group (i.e. a diazochromophore) with the CD spectra of other L-alanine-based polyisocyanides a right-handed (P) helical backbone geometry has been assigned to these polymers.

Original languageEnglish
Pages (from-to)1625-1630
Number of pages6
JournalMacromolecular chemistry and physics
Volume203
Issue number10-11
DOIs
Publication statusPublished - 29 Jul 2002

Keywords

  • CD spectroscopy
  • Chiral
  • Conformational analysis
  • Helical polymers
  • Self-organization

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