Determination of the helical sense in alanine based polyisocyanides

Jeroen J.L.M. Cornelissen; Nico A.J.M. Sommerdijk; Roeland J.M. Nolte

doi:10.1002/1521-3935(200207)203:10/11<1625::AID-MACP1625>3.0.CO;2-R

Determination of the helical sense in alanine based polyisocyanides

Jeroen J.L.M. Cornelissen, Nico A.J.M. Sommerdijk^*, Roeland J.M. Nolte

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The assignment of the helix sense in poly-(isocyano amino acids) and poly(isocyano peptides) using circular dichroism (CD) spectroscopy is hampered due to overlap of signals arising from the polymer backbone and the side chains. By comparing the CD spectrum of an L-alanine based polyisocyanide containing a spectator group (i.e. a diazochromophore) with the CD spectra of other L-alanine-based polyisocyanides a right-handed (P) helical backbone geometry has been assigned to these polymers.

Original language	English
Pages (from-to)	1625-1630
Number of pages	6
Journal	Macromolecular chemistry and physics
Volume	203
Issue number	10-11
DOIs	https://doi.org/10.1002/1521-3935(200207)203:10/11<1625::AID-MACP1625>3.0.CO;2-R
Publication status	Published - 29 Jul 2002

Keywords

CD spectroscopy
Chiral
Conformational analysis
Helical polymers
Self-organization

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10.1002/1521-3935(200207)203:10/11<1625::AID-MACP1625>3.0.CO;2-R

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title = "Determination of the helical sense in alanine based polyisocyanides",

abstract = "The assignment of the helix sense in poly-(isocyano amino acids) and poly(isocyano peptides) using circular dichroism (CD) spectroscopy is hampered due to overlap of signals arising from the polymer backbone and the side chains. By comparing the CD spectrum of an L-alanine based polyisocyanide containing a spectator group (i.e. a diazochromophore) with the CD spectra of other L-alanine-based polyisocyanides a right-handed (P) helical backbone geometry has been assigned to these polymers.",

keywords = "CD spectroscopy, Chiral, Conformational analysis, Helical polymers, Self-organization",

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T1 - Determination of the helical sense in alanine based polyisocyanides

AU - Cornelissen, Jeroen J.L.M.

AU - Sommerdijk, Nico A.J.M.

AU - Nolte, Roeland J.M.

PY - 2002/7/29

Y1 - 2002/7/29

N2 - The assignment of the helix sense in poly-(isocyano amino acids) and poly(isocyano peptides) using circular dichroism (CD) spectroscopy is hampered due to overlap of signals arising from the polymer backbone and the side chains. By comparing the CD spectrum of an L-alanine based polyisocyanide containing a spectator group (i.e. a diazochromophore) with the CD spectra of other L-alanine-based polyisocyanides a right-handed (P) helical backbone geometry has been assigned to these polymers.

AB - The assignment of the helix sense in poly-(isocyano amino acids) and poly(isocyano peptides) using circular dichroism (CD) spectroscopy is hampered due to overlap of signals arising from the polymer backbone and the side chains. By comparing the CD spectrum of an L-alanine based polyisocyanide containing a spectator group (i.e. a diazochromophore) with the CD spectra of other L-alanine-based polyisocyanides a right-handed (P) helical backbone geometry has been assigned to these polymers.

KW - CD spectroscopy

KW - Chiral

KW - Conformational analysis

KW - Helical polymers

KW - Self-organization

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U2 - 10.1002/1521-3935(200207)203:10/11<1625::AID-MACP1625>3.0.CO;2-R

DO - 10.1002/1521-3935(200207)203:10/11<1625::AID-MACP1625>3.0.CO;2-R

M3 - Article

AN - SCOPUS:0037194065

SN - 1022-1352

VL - 203

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EP - 1630

JO - Macromolecular chemistry and physics

JF - Macromolecular chemistry and physics

IS - 10-11

ER -

Determination of the helical sense in alanine based polyisocyanides

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Keywords

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