Developing a stochastic model for acousto-optic tissue imaging

Steffen Resink, Wiendelt Steenbergen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Direct optical measurements in scattering media offer poor resolution due to the high scattering. Ultrasound is scattered orders of magnitude less in tissue compared with light and therefore offers good resolution. Photoacoustics and acoustooptics are both relatively new hybrid techniques that enable measurements of optical properties in scattering media by combining ultrasound and light. Quantified measurements of the fluence and absorption coefficient however are desired and can not be performed by these separate techniques. A new approach to achieve this goal is to combine both hybrid techniques. By combining photoacoustic and acousto-optic measurements there is sufficient information to calculate the absorption coefficient and fluence at the ultrasound focus used for the acousto-optics. We require knowledge on the interaction of light and sound inside tissue, so the size of the so called tagging volume can be determined. This tagging volume is defined by the size and shape of the ultrasound focus used in the acousto-optic measurements. A stochastic model for acousto-optics is under development that used existing knowledge on the in the interaction between light and sound. By separating light transport and the interactions of light and sound and writing this interaction as a probability density function it is possible to find the effective geometrical properties of the tagging volume. At the moment multiple interaction mechanisms of sound and light are added to this model. In the future this model will be validated in phantoms and biological tissue.
Original languageEnglish
Title of host publicationPhotons Plus Ultrasound: Imaging and Sensing 2012
Place of PublicationSan Francisco
PublisherSPIE
Pages-
DOIs
Publication statusPublished - 2012
EventPhotons Plus Ultrasound: Imaging and Sensing, SPIE BiOS 2012 - San Francisco, United States
Duration: 22 Jan 201224 Jan 2012

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume8223
ISSN (Print)0277-786X

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing, SPIE BiOS 2012
Abbreviated titleSPIE BiOS
CountryUnited States
CitySan Francisco
Period22/01/1224/01/12

Keywords

  • METIS-289522
  • IR-83219

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