Development and validation of a system based on spectral-photometry for measuring fluid dynamics of multi-infusion conditions in intensive care units

Annemoon Timmerman*, Brechtje Riphagen, John Klaessens, Rudolf Verdaasdonk

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Multi-infusion setups for medication administration in Intensive Care Units seem uncontrolled due to flow and pressure differences between syringe pumps. To investigate the dynamics and interaction of multi-infusion, a dedicated set-up was developed to measure the concentrations of fluids dynamically in multiple lines using absorption spectral-photometry. For feasibility testing and calibration, various dyes and concentrations were investigated to find the optimal settings. The developed method was validated and showed satisfactory results for determining mixtures of up to three different dyes in different ratios, with average recoveries of 105.0% (±11.01) for two dyes and 99.6% (±6.26) for three dyes. The method was applied in initial simulation experiments for measuring effects of manipulations in a multi-infusion set-up simulating a clinical situation. Results showed evidence for mutual influencing of separate infusion lines. The method developed for measuring the fluid dynamics of multi-infusion will contribute to a better insight and controlled administration of medications.

Original languageEnglish
Title of host publicationDesign and Quality for Biomedical Technologies II
DOIs
Publication statusPublished - 18 Sep 2009
Externally publishedYes
EventDesign and Quality for Biomedical Technologies II 2009 - San Jose, United States
Duration: 26 Jan 200926 Jan 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7170
ISSN (Print)1605-7422

Conference

ConferenceDesign and Quality for Biomedical Technologies II 2009
CountryUnited States
CitySan Jose
Period26/01/0926/01/09

Keywords

  • Fluid dynamics
  • Method development
  • Multi-infusion system
  • Quality
  • Safety
  • Simultaneous analysis
  • Spectrophotometry

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