Development and validation of clinical prediction models: Marginal differences between logistic regression, penalized maximum likelihood estimation, and genetic programming

Kristel J.M. Janssen*, Ivar Siccama, Yvonne Vergouwe, Hendrik Koffijberg, Thomas P.A. Debray, Maarten Keijzer, Diederick E. Grobbee, Karel G.M. Moons

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
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Objective: Many prediction models are developed by multivariable logistic regression. However, there are several alternative methods to develop prediction models. We compared the accuracy of a model that predicts the presence of deep venous thrombosis (DVT) when developed by four different methods.

Study Design and Setting: We used the data of 2,086 primary care patients suspected of DVT, which included 21 candidate predictors. The cohort was split into a derivation set (1,668 patients, 329 with DVT) and a validation set (418 patients, 86 with DVT). Also, 100 cross-validations were conducted in the full cohort. The models were developed by logistic regression, logistic regression with shrinkage by bootstrapping techniques, logistic regression with shrinkage by penalized maximum likelihood estimation, and genetic programming. The accuracy of the models was tested by assessing discrimination and calibration.

Results: There were only marginal differences in the discrimination and calibration of the models in the validation set and cross-validations. Conclusion: The accuracy measures of the models developed by the four different methods were only slightly different, and the 95% confidence intervals were mostly overlapped. We have shown that models with good predictive accuracy are most likely developed by sensible modeling strategies rather than by complex development methods.
Original languageEnglish
Pages (from-to)404-412
Number of pages9
JournalJournal of clinical epidemiology
Issue number4
Publication statusPublished - 1 Apr 2012


  • Genetic programming
  • Logistic regression
  • Penalized maximum likelihood estimation
  • Prediction model

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