Development of a combined, highly integrated extracorporeal lung and kidney support device (RenOx): Evaluation of fibre configurations on gas exchange preservation

Ana Martins Costa, Bettina Wiegmann, Jan-Niklas Thiel, Michael Neidlin, F.R. Halfwerk, Jutta Arens

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Abstract

Objectives: We aim to develop a novel artificial lung that integrates lung and kidney support in a single device by combining oxygenation and haemodialysis fibres in the same housing. For this, we investigated how many oxygenation fibres can be replaced by haemodialysis fibres to maintain 90% of the oxygenator's gas exchange capacity and what influence fibre configuration has on this.
Methods: Fibre bundles consisted of stacked oxygenation fibre mats (Oxyplus™ 90/200,3M) placed perpendicularly and/or crossed in a 24° angle on top of each other. Bundles in perpendicular configuration had 50% of fibres closed (Oxy50P), 25% fibres closed (Oxy75P), or all fibres open (Oxy100P). Bundles in crossed configuration had ⅓ of fibres closed (Oxy67C), or all fibres open (Oxy100C). Closed fibres did not contribute to gas exchange, simulating haemodialysis fibres. Oxygen transfer was measured during blood tests performed according to ISO 7199:2016.
Results: Results show that 25% of oxygenation fibre layers in perpendicular configuration could be closed keeping 90% of the oxygen exchange efficiency of our oxygenator. We found no statistically significant difference in oxygen transfer for bundles with 25% of perpendicular fibres closed and bundles with all fibres open. Moreover, up to 140 mL/min, these bundles were able to deliver oxygen above 55 mLOxygen/LBlood. A higher number of fibres could be closed in perpendicular than in 24° angle causing a lower decrease in oxygen transfer. Below 140 mL/min, closing 33% of 24° angled fibres or 50% of perpendicular fibres resulted in an equal decrease in oxygen transfer by 20%.Conclusions: Results show that 25% perpendicular oxygenation fibres can be replaced by haemodialysis fibres maintaining 90% of the oxygen exchange capacity of our oxygenator. This is one step towards combining pulmonary-renal support in one device.
Original languageEnglish
Pages (from-to)140-141
Number of pages2
JournalPerfusion
Volume38
Issue number1 suppl
DOIs
Publication statusPublished - May 2023
Event11th EuroELSO Congress 2023 - Lisboa Congress Centre, Lisbon, Portugal
Duration: 26 Apr 202329 Apr 2023
Conference number: 11

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