Development of a neural probe to measure potassium during a cortical spreading depression in-vivo

E.J. van der Wouden, E.A. Tolner, Mathieu Odijk, Wouter Olthuis, A.M.J.M. van den Maagdenburg, M.D. Ferrari, Albert van den Berg

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Cortical Spreading Depression (CSD) is a key event in migraine; during a CSD a wave of depolarization spreads through the brain, starting in the visual cortex. We present the design and fabrication of a novel probe that can be functionalized to measure multiple parameters, relevant to a CSD, in-vivo simultaneously. In this work, we focus on the functionalization of the fabricated probes to measure extracellular potassium with a potentiometric sensor. The sensor response is approximately linear from 2-40 mM, and has a response of 55 mV/log[K+]. Measurements where performed in-vivo in a WT mouse and clearly indicated raised potassium levels during the evoked CSD.
    Original languageUndefined
    Title of host publication17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII
    Place of PublicationBarcelona
    PublisherIEEE
    Pages2145-2148
    Number of pages4
    ISBN (Print)978-1-4673-5983-2
    DOIs
    Publication statusPublished - 16 Jun 2013
    Event17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2013 - Barcelona, Spain
    Duration: 16 Jun 201320 Jun 2013
    Conference number: 17
    http://www.transducers-eurosensors2013.org/

    Publication series

    NameTransducers
    PublisherIEEE

    Conference

    Conference17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2013
    Abbreviated titleTRANSDUCERS 2013
    CountrySpain
    CityBarcelona
    Period16/06/1320/06/13
    OtherHeld in conjunction with EUROSENSORS XXVII
    Internet address

    Keywords

    • EWI-24084
    • METIS-300211
    • IR-88246

    Cite this

    van der Wouden, E. J., Tolner, E. A., Odijk, M., Olthuis, W., van den Maagdenburg, A. M. J. M., Ferrari, M. D., & van den Berg, A. (2013). Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. In 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII (pp. 2145-2148). (Transducers). Barcelona: IEEE. https://doi.org/10.1109/Transducers.2013.6627226
    van der Wouden, E.J. ; Tolner, E.A. ; Odijk, Mathieu ; Olthuis, Wouter ; van den Maagdenburg, A.M.J.M. ; Ferrari, M.D. ; van den Berg, Albert. / Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII. Barcelona : IEEE, 2013. pp. 2145-2148 (Transducers).
    @inproceedings{df3b72338a1a4baf86338a03debe9711,
    title = "Development of a neural probe to measure potassium during a cortical spreading depression in-vivo",
    abstract = "Cortical Spreading Depression (CSD) is a key event in migraine; during a CSD a wave of depolarization spreads through the brain, starting in the visual cortex. We present the design and fabrication of a novel probe that can be functionalized to measure multiple parameters, relevant to a CSD, in-vivo simultaneously. In this work, we focus on the functionalization of the fabricated probes to measure extracellular potassium with a potentiometric sensor. The sensor response is approximately linear from 2-40 mM, and has a response of 55 mV/log[K+]. Measurements where performed in-vivo in a WT mouse and clearly indicated raised potassium levels during the evoked CSD.",
    keywords = "EWI-24084, METIS-300211, IR-88246",
    author = "{van der Wouden}, E.J. and E.A. Tolner and Mathieu Odijk and Wouter Olthuis and {van den Maagdenburg}, A.M.J.M. and M.D. Ferrari and {van den Berg}, Albert",
    note = "10.1109/Transducers.2013.6627226",
    year = "2013",
    month = "6",
    day = "16",
    doi = "10.1109/Transducers.2013.6627226",
    language = "Undefined",
    isbn = "978-1-4673-5983-2",
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    publisher = "IEEE",
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    booktitle = "17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII",
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    }

    van der Wouden, EJ, Tolner, EA, Odijk, M, Olthuis, W, van den Maagdenburg, AMJM, Ferrari, MD & van den Berg, A 2013, Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. in 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII. Transducers, IEEE, Barcelona, pp. 2145-2148, 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2013, Barcelona, Spain, 16/06/13. https://doi.org/10.1109/Transducers.2013.6627226

    Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. / van der Wouden, E.J.; Tolner, E.A.; Odijk, Mathieu; Olthuis, Wouter; van den Maagdenburg, A.M.J.M.; Ferrari, M.D.; van den Berg, Albert.

    17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII. Barcelona : IEEE, 2013. p. 2145-2148 (Transducers).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    AU - van der Wouden, E.J.

    AU - Tolner, E.A.

    AU - Odijk, Mathieu

    AU - Olthuis, Wouter

    AU - van den Maagdenburg, A.M.J.M.

    AU - Ferrari, M.D.

    AU - van den Berg, Albert

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    N2 - Cortical Spreading Depression (CSD) is a key event in migraine; during a CSD a wave of depolarization spreads through the brain, starting in the visual cortex. We present the design and fabrication of a novel probe that can be functionalized to measure multiple parameters, relevant to a CSD, in-vivo simultaneously. In this work, we focus on the functionalization of the fabricated probes to measure extracellular potassium with a potentiometric sensor. The sensor response is approximately linear from 2-40 mM, and has a response of 55 mV/log[K+]. Measurements where performed in-vivo in a WT mouse and clearly indicated raised potassium levels during the evoked CSD.

    AB - Cortical Spreading Depression (CSD) is a key event in migraine; during a CSD a wave of depolarization spreads through the brain, starting in the visual cortex. We present the design and fabrication of a novel probe that can be functionalized to measure multiple parameters, relevant to a CSD, in-vivo simultaneously. In this work, we focus on the functionalization of the fabricated probes to measure extracellular potassium with a potentiometric sensor. The sensor response is approximately linear from 2-40 mM, and has a response of 55 mV/log[K+]. Measurements where performed in-vivo in a WT mouse and clearly indicated raised potassium levels during the evoked CSD.

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    BT - 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII

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    van der Wouden EJ, Tolner EA, Odijk M, Olthuis W, van den Maagdenburg AMJM, Ferrari MD et al. Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. In 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII. Barcelona: IEEE. 2013. p. 2145-2148. (Transducers). https://doi.org/10.1109/Transducers.2013.6627226