Development of a neural probe to measure potassium during a cortical spreading depression in-vivo

E.J. van der Wouden, E.A. Tolner, Mathieu Odijk, Wouter Olthuis, A.M.J.M. van den Maagdenburg, M.D. Ferrari, Albert van den Berg

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Cortical Spreading Depression (CSD) is a key event in migraine; during a CSD a wave of depolarization spreads through the brain, starting in the visual cortex. We present the design and fabrication of a novel probe that can be functionalized to measure multiple parameters, relevant to a CSD, in-vivo simultaneously. In this work, we focus on the functionalization of the fabricated probes to measure extracellular potassium with a potentiometric sensor. The sensor response is approximately linear from 2-40 mM, and has a response of 55 mV/log[K+]. Measurements where performed in-vivo in a WT mouse and clearly indicated raised potassium levels during the evoked CSD.
    Original languageUndefined
    Title of host publication17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII
    Place of PublicationBarcelona
    PublisherIEEE
    Pages2145-2148
    Number of pages4
    ISBN (Print)978-1-4673-5983-2
    DOIs
    Publication statusPublished - 16 Jun 2013
    Event17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2013 - Barcelona, Spain
    Duration: 16 Jun 201320 Jun 2013
    Conference number: 17
    http://www.transducers-eurosensors2013.org/

    Publication series

    NameTransducers
    PublisherIEEE

    Conference

    Conference17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2013
    Abbreviated titleTRANSDUCERS 2013
    CountrySpain
    CityBarcelona
    Period16/06/1320/06/13
    OtherHeld in conjunction with EUROSENSORS XXVII
    Internet address

    Keywords

    • EWI-24084
    • METIS-300211
    • IR-88246

    Cite this

    van der Wouden, E. J., Tolner, E. A., Odijk, M., Olthuis, W., van den Maagdenburg, A. M. J. M., Ferrari, M. D., & van den Berg, A. (2013). Development of a neural probe to measure potassium during a cortical spreading depression in-vivo. In 17th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers & Eurosensors XXVII (pp. 2145-2148). (Transducers). Barcelona: IEEE. https://doi.org/10.1109/Transducers.2013.6627226