Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué; J. Feijen; J.F.J. Engbersen

doi:10.1016/j.jconrel.2008.09.040

Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué^*, J. Feijen, J.F.J. Engbersen

^*Corresponding author for this work

Research output: Contribution to journal › Meeting Abstract › Academic

187 Citations (Scopus)

Abstract

Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

Original language	English
Pages (from-to)	e2-e3
Journal	Journal of controlled release
Volume	132
Issue number	3
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.040
Publication status	Published - 2 Apr 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

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title = "Development of biodegradable poly(amidoamine)s for protein delivery",

abstract = "Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.",

author = "G. Cou{\'e} and J. Feijen and J.F.J. Engbersen",

year = "2008",

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doi = "10.1016/j.jconrel.2008.09.040",

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journal = "Journal of controlled release",

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TY - JOUR

T1 - Development of biodegradable poly(amidoamine)s for protein delivery

AU - Coué, G.

AU - Feijen, J.

AU - Engbersen, J.F.J.

N1 - Conference code: 10

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

AB - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

U2 - 10.1016/j.jconrel.2008.09.040

DO - 10.1016/j.jconrel.2008.09.040

M3 - Meeting Abstract

VL - 132

SP - e2-e3

JO - Journal of controlled release

JF - Journal of controlled release

SN - 0168-3659

IS - 3

T2 - 10th European Symposium on Controlled Drug Delivery, ESCDD 2008

Y2 - 2 April 2008 through 4 April 2008

ER -