Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué; W.E. Hennink; G.M.J.P.C. Coué; J. Feijen; Jan Feijen; A.P. Sam; Johannes F.J. Engbersen

doi:10.1016/j.jconrel.2008.09.040

Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué, W.E. Hennink (Editor), G.M.J.P.C. Coué, J. Feijen (Editor), Jan Feijen, A.P. Sam (Editor), Johannes F.J. Engbersen

Research output: Contribution to conference › Paper

Abstract

Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

Original language	Undefined
Pages	-e2
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.040
Publication status	Published - 2 Apr 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

Conference

Conference	10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated title	ESCDD
Country	Netherlands
City	Noordwijk aan Zee
Period	2/04/08 → 4/04/08

Keywords

METIS-254621
IR-68971

Access to Document

10.1016/j.jconrel.2008.09.040

Cite this

Coué, G., Hennink, W. E. (Ed.), Coué, G. M. J. P. C., Feijen, J. (Ed.), Feijen, J., Sam, A. P. (Ed.), & Engbersen, J. F. J. (2008). Development of biodegradable poly(amidoamine)s for protein delivery. -e2. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.040

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abstract = "Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.",

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doi = "10.1016/j.jconrel.2008.09.040",

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Development of biodegradable poly(amidoamine)s for protein delivery. / Coué, G.; Hennink, W.E. (Editor); Coué, G.M.J.P.C.; Feijen, J. (Editor); Feijen, Jan; Sam, A.P. (Editor); Engbersen, Johannes F.J.

2008. -e2 Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.

Research output: Contribution to conference › Paper

TY - CONF

T1 - Development of biodegradable poly(amidoamine)s for protein delivery

AU - Coué, G.

AU - Coué, G.M.J.P.C.

AU - Feijen, Jan

AU - Engbersen, Johannes F.J.

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, A.P.

PY - 2008/4/2

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N2 - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

AB - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

KW - METIS-254621

KW - IR-68971

U2 - 10.1016/j.jconrel.2008.09.040

DO - 10.1016/j.jconrel.2008.09.040

M3 - Paper

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