Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.
|Journal||Journal of controlled release|
|Publication status||Published - 2 Apr 2008|
|Event||10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands|
Duration: 2 Apr 2008 → 4 Apr 2008
Conference number: 10