Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué*, J. Feijen, J.F.J. Engbersen

*Corresponding author for this work

Research output: Contribution to journalMeeting AbstractAcademic

187 Citations (Scopus)

Abstract

Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.
Original languageEnglish
Pages (from-to)e2-e3
JournalJournal of controlled release
Volume132
Issue number3
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

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