Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué, W.E. Hennink (Editor), G.M.J.P.C. Coué, J. Feijen (Editor), Jan Feijen, A.P. Sam (Editor), Johannes F.J. Engbersen

Research output: Contribution to conferencePaperAcademic

Abstract

Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.
Original languageUndefined
Pages-e2
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • METIS-254621
  • IR-68971

Cite this

Coué, G., Hennink, W. E. (Ed.), Coué, G. M. J. P. C., Feijen, J. (Ed.), Feijen, J., Sam, A. P. (Ed.), & Engbersen, J. F. J. (2008). Development of biodegradable poly(amidoamine)s for protein delivery. -e2. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.040
Coué, G. ; Hennink, W.E. (Editor) ; Coué, G.M.J.P.C. ; Feijen, J. (Editor) ; Feijen, Jan ; Sam, A.P. (Editor) ; Engbersen, Johannes F.J. / Development of biodegradable poly(amidoamine)s for protein delivery. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.
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title = "Development of biodegradable poly(amidoamine)s for protein delivery",
abstract = "Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.",
keywords = "METIS-254621, IR-68971",
author = "G. Cou{\'e} and W.E. Hennink and G.M.J.P.C. Cou{\'e} and J. Feijen and Jan Feijen and A.P. Sam and Engbersen, {Johannes F.J.}",
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month = "4",
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doi = "10.1016/j.jconrel.2008.09.040",
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Coué, G, Hennink, WE (ed.), Coué, GMJPC, Feijen, J (ed.), Feijen, J, Sam, AP (ed.) & Engbersen, JFJ 2008, 'Development of biodegradable poly(amidoamine)s for protein delivery' Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands, 2/04/08 - 4/04/08, pp. -e2. https://doi.org/10.1016/j.jconrel.2008.09.040

Development of biodegradable poly(amidoamine)s for protein delivery. / Coué, G.; Hennink, W.E. (Editor); Coué, G.M.J.P.C.; Feijen, J. (Editor); Feijen, Jan; Sam, A.P. (Editor); Engbersen, Johannes F.J.

2008. -e2 Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.

Research output: Contribution to conferencePaperAcademic

TY - CONF

T1 - Development of biodegradable poly(amidoamine)s for protein delivery

AU - Coué, G.

AU - Coué, G.M.J.P.C.

AU - Feijen, Jan

AU - Engbersen, Johannes F.J.

A2 - Hennink, W.E.

A2 - Feijen, J.

A2 - Sam, A.P.

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

AB - Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.

KW - METIS-254621

KW - IR-68971

U2 - 10.1016/j.jconrel.2008.09.040

DO - 10.1016/j.jconrel.2008.09.040

M3 - Paper

SP - -e2

ER -

Coué G, Hennink WE, (ed.), Coué GMJPC, Feijen J, (ed.), Feijen J, Sam AP, (ed.) et al. Development of biodegradable poly(amidoamine)s for protein delivery. 2008. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.040