Development of biodegradable poly(amidoamine)s for protein delivery

G. Coué, W.E. Hennink (Editor), G.M.J.P.C. Coué, J. Feijen (Editor), Jan Feijen, A.P. Sam (Editor), Johannes F.J. Engbersen

Research output: Contribution to conferencePaper

Abstract

Novel bioreducible poly(amido amine)s containing disulfide linkages were synthesized and evaluated as vectors for protein delivery. These linear polymers could be easily obtained by Michael-type polyaddition of various primary amines to the disulfide-containing cystaminebisacrylamide. The polymers efficiently condense protein into nanoscaled and positively charged complexes that are stable under neutral conditions but rapidly destabilize in a reductive environment. The results indicate that bioreducible poly(amido amine)s have excellent properties as highly potent and nontoxic protein carriers.
Original languageUndefined
Pages-e2
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • METIS-254621
  • IR-68971

Cite this

Coué, G., Hennink, W. E. (Ed.), Coué, G. M. J. P. C., Feijen, J. (Ed.), Feijen, J., Sam, A. P. (Ed.), & Engbersen, J. F. J. (2008). Development of biodegradable poly(amidoamine)s for protein delivery. -e2. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.040