Development of novel membranes for blood purification therapies based on copolymers of N-vinylpyrrolidone and n-butylmethacrylate

M.S.L. Tijink, J. Janssen, M. Timmer, J. Austen, Y. Aldenhoff, J. Kooman, L.H. Koole, J. Damoiseaux, R. van Oerle, Y. Henskens, D. Stamatialis

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
149 Downloads (Pure)


Developments in membrane based blood purification therapies often come with longer treatment times and therefore longer blood–material contact, which requires long-term membrane biocompatibility. In this study, we develop for the first time membranes for blood purification using the material SlipSkin™, which is a copolymer, made from N-vinylpyrrolidone (NVP) and butylmethacrylate (BMA). Specific attention is focused on understanding the mechanism of pore formation and the tailoring of the membrane mechanical and transport properties to obtain the optimal membrane for blood purification therapies. Polymer composition, solvent type and solvent evaporation time influence membrane morphology and membranes with sieving properties of cascade filters in plasma fractionation applications are developed. The new membranes have very good blood compatibility properties; in fact compared to benchmark flat membranes currently used in the clinic, they have lower platelet adhesion while all other properties (contact activation, thrombogenicity, leukocyte adhesion, hemolysis and complement activation) are also very good and comparable to the benchmarks.
Original languageEnglish
Pages (from-to)6066-6077
JournalJournal of materials chemistry. B: materials for biology and medicine
Issue number44
Publication statusPublished - 2013

Cite this