TY - JOUR
T1 - Development of polyvinlyl alcohol-chitosan-hydroxypropylmethylcellulose based composite films for controlled drug delivery
AU - Gopalakrishnan, Saran
AU - Dathathri, Eshwari
AU - Thakur, Goutam
AU - Koteshwara, K. B.
N1 - Funding Information:
The authors sincerely thank Dr. N.V Anil Kumar and Mr. Shivanand.M.Shettigar for their technical support and guidance. The authors also acknowledge the funding from Manipal University (MIT/AD-R&C/Post Doc/2012, dated 30.11.2012).
Publisher Copyright:
© 2017 Society for Biomaterials and Artificial Organs - India. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The study aims at developing composite films of polyvinyl alcohol (PVA), chitosan (Cs) and Hydroxypropyl-methyl-cellulose (HPMC) using the solvent casting method. The films are developed with enhanced mechanical stability to help in reducing inflammation and providing the initial dressing to aid in wound healing. Films of different polymer ratios were developed and optimized for further characterization studies, the optimal blends were then selected for drug diffusion studies with curcumin. Films of HPMC:chitosan:PVA ratios of 1:1:1 and 1:1:2 have showed improved tensile strength (56.77 MPa and 113.76 MPa respectively), showed more sustained swelling for 25 minutes in comparison to other samples. FTIR analysis and SEM analysis indicated interaction among the polymers while its surface morphology being continuous and uniform. Film HPMC:chitosan:PVA ratio of 1:1:1 (HCP1) exhibited substantially efficient release of 16.38±0.126% over 3 hours and found best fit in zero order following non Fickian diffusion. The film characteristics and diffusion studies indicated that the drug-loaded film could hold good for its application in wound healing.
AB - The study aims at developing composite films of polyvinyl alcohol (PVA), chitosan (Cs) and Hydroxypropyl-methyl-cellulose (HPMC) using the solvent casting method. The films are developed with enhanced mechanical stability to help in reducing inflammation and providing the initial dressing to aid in wound healing. Films of different polymer ratios were developed and optimized for further characterization studies, the optimal blends were then selected for drug diffusion studies with curcumin. Films of HPMC:chitosan:PVA ratios of 1:1:1 and 1:1:2 have showed improved tensile strength (56.77 MPa and 113.76 MPa respectively), showed more sustained swelling for 25 minutes in comparison to other samples. FTIR analysis and SEM analysis indicated interaction among the polymers while its surface morphology being continuous and uniform. Film HPMC:chitosan:PVA ratio of 1:1:1 (HCP1) exhibited substantially efficient release of 16.38±0.126% over 3 hours and found best fit in zero order following non Fickian diffusion. The film characteristics and diffusion studies indicated that the drug-loaded film could hold good for its application in wound healing.
UR - http://www.scopus.com/inward/record.url?scp=85046098148&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85046098148
SN - 0971-1198
VL - 31
SP - 97
EP - 101
JO - Trends in Biomaterials and Artificial Organs
JF - Trends in Biomaterials and Artificial Organs
IS - 3
ER -
