Development of tissue adhesives based on amphiphilic isocyanate-terminated trimethylene carbonate block copolymers

Agnieszka Bochynska; Shahriar Sharifi; Tony G. van Tienen; Pieter Buma; Dirk W. Grijpma

doi:10.1002/masy.201300101

Development of tissue adhesives based on amphiphilic isocyanate-terminated trimethylene carbonate block copolymers

Agnieszka Bochynska, Shahriar Sharifi, Tony G. van Tienen, Pieter Buma, Dirk W. Grijpma

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond®, which is currently one of the strongest clinically used tissue adhesives

Original language	English
Pages (from-to)	40-48
Journal	Macromolecular symposia
Volume	334
Issue number	1
DOIs	https://doi.org/10.1002/masy.201300101
Publication status	Published - 2013
Event	533th WE-Heraeus-Seminar "Advanced Functional Polymers in Medicine" 2013 - Bad Honnef, Germany Duration: 27 May 2013 → 29 May 2013

Keywords

METIS-300406
IR-90078

Access to Document

10.1002/masy.201300101

Cite this

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title = "Development of tissue adhesives based on amphiphilic isocyanate-terminated trimethylene carbonate block copolymers",

abstract = "In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond{\textregistered}, which is currently one of the strongest clinically used tissue adhesives",

keywords = "METIS-300406, IR-90078",

author = "Agnieszka Bochynska and Shahriar Sharifi and {van Tienen}, {Tony G.} and Pieter Buma and Grijpma, {Dirk W.}",

note = "Special Issue: Advanced Functional Polymers in Medicine ; 533th WE-Heraeus-Seminar {"}Advanced Functional Polymers in Medicine{"} 2013 ; Conference date: 27-05-2013 Through 29-05-2013",

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T1 - Development of tissue adhesives based on amphiphilic isocyanate-terminated trimethylene carbonate block copolymers

AU - Bochynska, Agnieszka

AU - Sharifi, Shahriar

AU - van Tienen, Tony G.

AU - Buma, Pieter

AU - Grijpma, Dirk W.

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PY - 2013

Y1 - 2013

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AB - In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond®, which is currently one of the strongest clinically used tissue adhesives

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