Development of tissue adhesives based on amphiphilic isocyanate-terminated trimethylene carbonate block copolymers

Agnieszka Bochynska, Shahriar Sharifi, Tony G. van Tienen, Pieter Buma, Dirk W. Grijpma

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In this study, novel 3-armed star-shaped isocyanate-terminated block copolymers based on trimethylolpropane ethoxylate (TMPE) and trimethylene carbonate (TMC) varying in composition were designed and synthesized. By reaction with water, networks were formed. The characteristics of these networks were compared with those prepared from analogous linear structures based on polyethylene glycol (PEG) and TMC. Tensile testing of the networks highlighted good mechanical properties. In lap shear adhesion tests to chamois leather, very good bonding strengths of up to 0.6 MPa were obtained. These values compare favorably with those of Dermabond®, which is currently one of the strongest clinically used tissue adhesives
Original languageEnglish
Pages (from-to)40-48
JournalMacromolecular symposia
Issue number1
Publication statusPublished - 2013
Event533th WE-Heraeus-Seminar "Advanced Functional Polymers in Medicine" 2013 - Bad Honnef, Germany
Duration: 27 May 201329 May 2013


  • METIS-300406
  • IR-90078

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