Dexamethasone nanomedicines for COVID-19

Twan Lammers; Alexandros Marios Sofias; Roy van der Meel; Raymond Schiffelers; Gert Storm; Frank Tacke; Steffen Koschmieder; Tim H. Brümmendorf; Fabian Kiessling; Josbert M. Metselaar

doi:10.1038/s41565-020-0752-z

Dexamethasone nanomedicines for COVID-19

Twan Lammers^*, Alexandros Marios Sofias, Roy van der Meel, Raymond Schiffelers, Gert Storm, Frank Tacke, Steffen Koschmieder, Tim H. Brümmendorf, Fabian Kiessling, Josbert M. Metselaar

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

141 Citations (Scopus)

48 Downloads (Pure)

Abstract

Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	Nature nanotechnology
Volume	15
Issue number	8
DOIs	https://doi.org/10.1038/s41565-020-0752-z
Publication status	Published - 3 Aug 2020

Keywords

22/2 OA procedure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41565-020-0752-z

Lammers-2020-Dexamethasone-nanomedicines-for-covFinal published version, 5.28 MBLicence: Taverne

Cite this

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title = "Dexamethasone nanomedicines for COVID-19",

abstract = "Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.",

keywords = "22/2 OA procedure",

author = "Twan Lammers and Sofias, {Alexandros Marios} and {van der Meel}, Roy and Raymond Schiffelers and Gert Storm and Frank Tacke and Steffen Koschmieder and Br{\"u}mmendorf, {Tim H.} and Fabian Kiessling and Metselaar, {Josbert M.}",

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T1 - Dexamethasone nanomedicines for COVID-19

AU - Lammers, Twan

AU - Sofias, Alexandros Marios

AU - van der Meel, Roy

AU - Schiffelers, Raymond

AU - Storm, Gert

AU - Tacke, Frank

AU - Koschmieder, Steffen

AU - Brümmendorf, Tim H.

AU - Kiessling, Fabian

AU - Metselaar, Josbert M.

PY - 2020/8/3

Y1 - 2020/8/3

N2 - Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

AB - Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

KW - 22/2 OA procedure

UR - http://www.scopus.com/inward/record.url?scp=85088866461&partnerID=8YFLogxK

U2 - 10.1038/s41565-020-0752-z

DO - 10.1038/s41565-020-0752-z

M3 - Comment/Letter to the editor

C2 - 32747742

AN - SCOPUS:85088866461

SN - 1748-3387

VL - 15

SP - 622

EP - 624

JO - Nature nanotechnology

JF - Nature nanotechnology

IS - 8

ER -

Dexamethasone nanomedicines for COVID-19

Abstract

Keywords

UN SDGs

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