TY - JOUR
T1 - Differences in screening history, tumour characteristics and survival between women with screen-detected versus not screen-detected cervical cancer in the east of The Netherlands, 1992–2001
AU - van der Aa, Maaike A.
AU - Schutter, Eltjo M.
AU - Looijen-Salamon, Monika
AU - Martens, Jolise E.
AU - Siesling, Sabine
PY - 2008
Y1 - 2008
N2 - Objective
In The Netherlands, despite a national screening programme since 1996, invasive cervical cancers have been detected in screened and non-screened women. The aim of this study was to determine differences between Pap-smear history, tumour characteristics and survival of patients with a tumour detected by the screening programme (SP) or outside the screening programme (OSP) in the region of the Comprehensive Cancer Centre Stedendriehoek Twente in the period 1992–2001.
Study design
In this period, 263 cervical cancer cases in women aged 30–60 were selected from the regional cancer registry. Patient and tumour characteristics, treatment and follow-up data were extracted. Also, detection modality of the tumour and Pap score of the smear which led to the diagnosis (‘diagnostic smear’) and the ‘previous smear’ were registered.
Results
Thirty-five percent were SP tumours and 65% were OSP tumours. SP tumours had a lower stage (FIGO I) than OSP tumours: 84% versus 57%. The OSP group exhibited a twofold increase in risk of death (p < 0.05) compared to the SP group. Subsequently 61 women (23%) and 46 (17%) women had an abnormal Pap smear (Pap II or higher) 5 and 3 years before the ‘diagnostic smear’, respectively. Furthermore, 37 women (14%) and 23 women (9%) had a normal smear 5 and 3 years before diagnosis, respectively.
Conclusion
SP tumours have a lower stage and a better prognosis, probably due to the fact that the screening programme detects the slow growing tumours which in general have a better prognosis. Furthermore, detection and treatment of patients with suspicious smears have been suboptimal and attention should therefore be paid to prompt follow-up of suspicious smears
AB - Objective
In The Netherlands, despite a national screening programme since 1996, invasive cervical cancers have been detected in screened and non-screened women. The aim of this study was to determine differences between Pap-smear history, tumour characteristics and survival of patients with a tumour detected by the screening programme (SP) or outside the screening programme (OSP) in the region of the Comprehensive Cancer Centre Stedendriehoek Twente in the period 1992–2001.
Study design
In this period, 263 cervical cancer cases in women aged 30–60 were selected from the regional cancer registry. Patient and tumour characteristics, treatment and follow-up data were extracted. Also, detection modality of the tumour and Pap score of the smear which led to the diagnosis (‘diagnostic smear’) and the ‘previous smear’ were registered.
Results
Thirty-five percent were SP tumours and 65% were OSP tumours. SP tumours had a lower stage (FIGO I) than OSP tumours: 84% versus 57%. The OSP group exhibited a twofold increase in risk of death (p < 0.05) compared to the SP group. Subsequently 61 women (23%) and 46 (17%) women had an abnormal Pap smear (Pap II or higher) 5 and 3 years before the ‘diagnostic smear’, respectively. Furthermore, 37 women (14%) and 23 women (9%) had a normal smear 5 and 3 years before diagnosis, respectively.
Conclusion
SP tumours have a lower stage and a better prognosis, probably due to the fact that the screening programme detects the slow growing tumours which in general have a better prognosis. Furthermore, detection and treatment of patients with suspicious smears have been suboptimal and attention should therefore be paid to prompt follow-up of suspicious smears
KW - IR-77712
KW - Treatment of patients with suspicious smears and follow-up suboptimal
KW - Pap smear history
KW - Screening programme
KW - Cervical cancer
U2 - 10.1016/j.ejogrb.2007.10.017
DO - 10.1016/j.ejogrb.2007.10.017
M3 - Article
VL - 139
SP - 204
EP - 209
JO - European journal of obstetrics and gynaecology and reproductive biology
JF - European journal of obstetrics and gynaecology and reproductive biology
SN - 0301-2115
IS - 2
ER -