Differential effects of bisphosphonates on breast cancer cell lines

R. Verdijk, H.R. Franke, F. Wolbers, I. Vermes

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    Bisphosphonates may induce direct anti-tumor effects in breast cancers cells in virtro. In this study, six bisphosphonates were administered to three breast caner cell lines. Cell proliferation was measured by quantification of th expressio of Cyclin D1 mRNA. Apoptosis was determined by flow cytometry of a DNA fragmentation assay. We demonstrated that bisphosphonates have direct effects on cell proliferation and apoptosis in different breast cander cell lines. However, not all bisphosphonates act equally on breast cancer cells in vitro. Zoledronate seems to be the most potent of the six bisphosphonates. This in vitro study showed that bisphosphonates possess promising anti-tumor potential.
    Original languageUndefined
    Article number10.1016/j.canlet.2006.03.011
    Pages (from-to)308-312
    Number of pages5
    JournalCancer letters
    Issue numberLNCS4549/1-2
    Publication statusPublished - 10 Mar 2007


    • METIS-241781
    • EWI-10767
    • IR-61845

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