Differentiation of tremor disorders with fMRI: A novel quantitative approach

S. Sharifi, W. Mugge, F. Luft, A.C. Schouten, T.H. Heida, L.J. Bour, A.F. van Rootselaar

Research output: Contribution to journalMeeting AbstractOther research output

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Abstract

Objective: To develop fMRI-based tools in tremor diagnostics and to demonstrate their clinical applicability. Background: Due to overlapping features of tremor disorders, clinical diagnostic tools are limited. Although seldomly used in diagnostic assessment of tremor, fMRI of pathological brain networks underlying tremor could aid accurate and early diagnosis. fMRI of the closed loop behaviour of the sensorimotor system may manifest itself differently with different tremor disorders and has not been fully explored yet in diagnostics.

Methods: Following a literature review that we performed on neuroimaging studies in essential tremor (ET), we developed a novel fMRI setup to investigate pathological brain networks related to tremor. An MR-compatible wrist manipulator, to perturb the sensorimotor loop, is combined with movement measures.

Results: Our review showed that current findings are consistent with the hypothesis that the cerebellothalamo-cortical network is involved in ET with a major role for the cerebellum. To date, imaging techniques roughly are divided into structural (n=11) and functional methods (n=24). Limitations include heterogeneity of ET symptoms, spatial resolution and inability to directly relate tremor to functional images. The typical nature of a sensorimotor loop is generally not taken into account. We have developed a high-end novel experimental setup within the MR-environment including artifact-free movement measures (EMG, accelerometry) and a MR-compatible wrist manipulator to apply perturbations. Perturbations applied close to pathological tremor frequencies provide sensory input in passive conditions and manipulate motor action in active conditions.

Conclusions: We introduce a multimodal fMRI set-up manipulating the sensorimotor loop to identify faulty brain circuitries. This system can potentially lead to a novel quantitative diagnostic tool for differentiating tremor and other movement disorders.
Original languageEnglish
Pages (from-to)157
Number of pages1
JournalMovement disorders
Volume28
Issue numberSuppl. 1
DOIs
Publication statusPublished - 2013

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Tremor
Magnetic Resonance Imaging
Essential Tremor
Wrist
Brain
Accelerometry
Movement Disorders
Neuroimaging
Artifacts
Cerebellum
Early Diagnosis

Keywords

  • EWI-24312
  • IR-89156
  • METIS-302644

Cite this

Sharifi, S. ; Mugge, W. ; Luft, F. ; Schouten, A.C. ; Heida, T.H. ; Bour, L.J. ; van Rootselaar, A.F. / Differentiation of tremor disorders with fMRI : A novel quantitative approach. In: Movement disorders. 2013 ; Vol. 28, No. Suppl. 1. pp. 157.
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Sharifi, S, Mugge, W, Luft, F, Schouten, AC, Heida, TH, Bour, LJ & van Rootselaar, AF 2013, 'Differentiation of tremor disorders with fMRI: A novel quantitative approach' Movement disorders, vol. 28, no. Suppl. 1, pp. 157. https://doi.org/10.1002/mds.25605

Differentiation of tremor disorders with fMRI : A novel quantitative approach. / Sharifi, S.; Mugge, W.; Luft, F.; Schouten, A.C.; Heida, T.H.; Bour, L.J.; van Rootselaar, A.F.

In: Movement disorders, Vol. 28, No. Suppl. 1, 2013, p. 157.

Research output: Contribution to journalMeeting AbstractOther research output

TY - JOUR

T1 - Differentiation of tremor disorders with fMRI

T2 - A novel quantitative approach

AU - Sharifi, S.

AU - Mugge, W.

AU - Luft, F.

AU - Schouten, A.C.

AU - Heida, T.H.

AU - Bour, L.J.

AU - van Rootselaar, A.F.

PY - 2013

Y1 - 2013

N2 - Objective: To develop fMRI-based tools in tremor diagnostics and to demonstrate their clinical applicability. Background: Due to overlapping features of tremor disorders, clinical diagnostic tools are limited. Although seldomly used in diagnostic assessment of tremor, fMRI of pathological brain networks underlying tremor could aid accurate and early diagnosis. fMRI of the closed loop behaviour of the sensorimotor system may manifest itself differently with different tremor disorders and has not been fully explored yet in diagnostics. Methods: Following a literature review that we performed on neuroimaging studies in essential tremor (ET), we developed a novel fMRI setup to investigate pathological brain networks related to tremor. An MR-compatible wrist manipulator, to perturb the sensorimotor loop, is combined with movement measures.Results: Our review showed that current findings are consistent with the hypothesis that the cerebellothalamo-cortical network is involved in ET with a major role for the cerebellum. To date, imaging techniques roughly are divided into structural (n=11) and functional methods (n=24). Limitations include heterogeneity of ET symptoms, spatial resolution and inability to directly relate tremor to functional images. The typical nature of a sensorimotor loop is generally not taken into account. We have developed a high-end novel experimental setup within the MR-environment including artifact-free movement measures (EMG, accelerometry) and a MR-compatible wrist manipulator to apply perturbations. Perturbations applied close to pathological tremor frequencies provide sensory input in passive conditions and manipulate motor action in active conditions. Conclusions: We introduce a multimodal fMRI set-up manipulating the sensorimotor loop to identify faulty brain circuitries. This system can potentially lead to a novel quantitative diagnostic tool for differentiating tremor and other movement disorders.

AB - Objective: To develop fMRI-based tools in tremor diagnostics and to demonstrate their clinical applicability. Background: Due to overlapping features of tremor disorders, clinical diagnostic tools are limited. Although seldomly used in diagnostic assessment of tremor, fMRI of pathological brain networks underlying tremor could aid accurate and early diagnosis. fMRI of the closed loop behaviour of the sensorimotor system may manifest itself differently with different tremor disorders and has not been fully explored yet in diagnostics. Methods: Following a literature review that we performed on neuroimaging studies in essential tremor (ET), we developed a novel fMRI setup to investigate pathological brain networks related to tremor. An MR-compatible wrist manipulator, to perturb the sensorimotor loop, is combined with movement measures.Results: Our review showed that current findings are consistent with the hypothesis that the cerebellothalamo-cortical network is involved in ET with a major role for the cerebellum. To date, imaging techniques roughly are divided into structural (n=11) and functional methods (n=24). Limitations include heterogeneity of ET symptoms, spatial resolution and inability to directly relate tremor to functional images. The typical nature of a sensorimotor loop is generally not taken into account. We have developed a high-end novel experimental setup within the MR-environment including artifact-free movement measures (EMG, accelerometry) and a MR-compatible wrist manipulator to apply perturbations. Perturbations applied close to pathological tremor frequencies provide sensory input in passive conditions and manipulate motor action in active conditions. Conclusions: We introduce a multimodal fMRI set-up manipulating the sensorimotor loop to identify faulty brain circuitries. This system can potentially lead to a novel quantitative diagnostic tool for differentiating tremor and other movement disorders.

KW - EWI-24312

KW - IR-89156

KW - METIS-302644

U2 - 10.1002/mds.25605

DO - 10.1002/mds.25605

M3 - Meeting Abstract

VL - 28

SP - 157

JO - Movement disorders

JF - Movement disorders

SN - 0885-3185

IS - Suppl. 1

ER -